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Intracellular Kinase & Adaptor Protein Antibodies

After binding of a ligand or secreted factor to its cell surface receptor, an intracellular signal is transduced, which is mediated by enzymatic activity of the receptor itself, as in the case of receptor tyrosine kinases, and by effector or adaptor proteins bound to specific intracellular domains of the receptor.

In the case of receptor tyrosine kinases, the intracellular domain of the receptor itself possesses tyrosine kinase activity and is able to phosphorylate and activate itself. This phosphorylated residue then serves as a docking site for adaptor proteins, which initiate activation and signaling by a cascade of protein kinases. These adaptor proteins bind the phosphorylated receptor via specific protein domains, such as SH2 and SH3 domains. These signaling pathways generally culminate in activation of transcription factors in the nucleus, which alter transcription and gene expression.

A well-known pathway of intracellular kinases is the mitogen-activated protein kinase (MAPK) pathway, which involves successive phosphorylation and activation of the serine/threonine protein kinases Ras, Raf, MEK and MAPK or extracellular signal-regulated kinase (ERK). ERK then translocates to the nucleus and activates transcription factors, such as Myc. The constitutive activation of this and other signaling pathways has been implicated in cancer progression, as the unattenuated signal can lead to uncontrolled cellular proliferation. Other important kinase signaling pathways include the phosphaditylinositol-3-phosphate kinase (PI3K) and Protein Kinase B (AKT) pathway and the p38 signaling pathways. In the case of signals mediated by G-protein coupled receptors, G-proteins are the intracellular adaptor proteins bound to the receptors cytoplasmic domain which initiate the signal. The cyclic AMP and phosphaditylinositol pathways are the major signaling pathways that mediate signaling downstream of G-protein coupled receptors.
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ARHGEF18 Polyclonal Antibody, FITC Conjugated
ARHGEF18 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A63336-05050 µg $256.00 Add to Cart
A63336-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF18 Polyclonal Antibody, FITC Conjugated
ARHGEF18 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51715-05050 µg $256.00 Add to Cart
A51715-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF18 Polyclonal Antibody, HRP Conjugated
ARHGEF18 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A51714-05050 µg $256.00 Add to Cart
A51714-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF18 Polyclonal Antibody, HRP Conjugated
ARHGEF18 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A63335-05050 µg $256.00 Add to Cart
A63335-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF39 Polyclonal Antibody
ARHGEF39 Polyclonal Antibody

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A58130-02020 µg $59.00 Add to Cart
A58130-05050 µg $256.00 Add to Cart
A58130-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF39 Polyclonal Antibody, Biotin Conjugated
ARHGEF39 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58131-05050 µg $256.00 Add to Cart
A58131-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF39 Polyclonal Antibody, FITC Conjugated
ARHGEF39 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58132-05050 µg $256.00 Add to Cart
A58132-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF39 Polyclonal Antibody, HRP Conjugated
ARHGEF39 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58133-05050 µg $256.00 Add to Cart
A58133-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF7 Polyclonal Antibody
ARHGEF7 Polyclonal Antibody

Application: ELISA, IF, IP
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A53117-02020 µg $59.00 Add to Cart
A53117-05050 µg $256.00 Add to Cart
A53117-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF7 Polyclonal Antibody, Biotin Conjugated
ARHGEF7 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A53114-05050 µg $256.00 Add to Cart
A53114-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF7 Polyclonal Antibody, FITC Conjugated
ARHGEF7 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A53115-05050 µg $256.00 Add to Cart
A53115-100100 µg $359.00 Add to Cart
Antibodies
ARHGEF7 Polyclonal Antibody, HRP Conjugated
ARHGEF7 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A53116-05050 µg $256.00 Add to Cart
A53116-100100 µg $359.00 Add to Cart
Antibodies
ARL1 Polyclonal Antibody
ARL1 Polyclonal Antibody

Application: ELISA, IF, IHC, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A68459-02020 µg $59.00 Add to Cart
A68459-05050 µg $249.00 Add to Cart
A68459-100100 µg $399.00 Add to Cart
Antibodies
ARL1 Polyclonal Antibody, Biotin Conjugated
ARL1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A68462-05050 µg $249.00 Add to Cart
A68462-100100 µg $399.00 Add to Cart
Antibodies
ARL1 Polyclonal Antibody, FITC Conjugated
ARL1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A68461-05050 µg $249.00 Add to Cart
A68461-100100 µg $399.00 Add to Cart
Antibodies
ARL1 Polyclonal Antibody, HRP Conjugated
ARL1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A68460-05050 µg $249.00 Add to Cart
A68460-100100 µg $399.00 Add to Cart
Antibodies
ARRB1 Polyclonal Antibody
ARRB1 Polyclonal Antibody

Application: ELISA, IF, IHC, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human, Rat
Trial Size Available: Yes
A62102-02020 µg $59.00 Add to Cart
A62102-05050 µg $256.00 Add to Cart
A62102-100100 µg $359.00 Add to Cart
Antibodies
ARRB1 Polyclonal Antibody, Biotin Conjugated
ARRB1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A62105-05050 µg $256.00 Add to Cart
A62105-100100 µg $359.00 Add to Cart
Antibodies
ARRB1 Polyclonal Antibody, FITC Conjugated
ARRB1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A62104-05050 µg $256.00 Add to Cart
A62104-100100 µg $359.00 Add to Cart
Antibodies
ARRB1 Polyclonal Antibody, HRP Conjugated
ARRB1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A62103-05050 µg $256.00 Add to Cart
A62103-100100 µg $359.00 Add to Cart
Antibodies
Result Pages: [<< Prev]   1  2  3  4  5 ...  [Next >>]  Displaying 61 to 80 (of 998 products)
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