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Feng L et. al. (September 2024). ALKBH5 regulates arginase 1 expression in MDSCs and their immunosuppressive activity in tumor-bearing host Noncoding RNA Res. 9(3):913-920.
This study investigates the role of ALKBH5 in regulating arginase 1 (Arg-1) expression and the immunosuppressive activity of myeloid-derived suppressor cells (MDSCs) in tumor-bearing hosts. The researchers found that decreased ALKBH5 expression in colorectal cancer (CRC) mice leads to elevated m6A levels in MDSCs, enhancing Arg-1 expression and immunosuppressive function, thus promoting tumor growth. These findings suggest that ALKBH5 may serve as a potential target for cancer immunotherapy by regulating MDSC function.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric), EpiQuik CUT&RUN m6A RNA Enrichment (MeRIP) Kit
Perez-Maldonado MA et. al. (April 2024). Influence of DNA-methylation at multiple stages of limb chondrogenesis Dev Biol.
This article investigates the influence of DNA methylation on multiple stages of limb chondrogenesis, focusing on its role in cell fate specification and gene expression regulation. The research demonstrates that DNA methylation dynamics are crucial for controlling chondrogenesis and cell fate decisions, with findings indicating that inhibiting DNA methylation can lead to ectopic digit formation and dysregulation of condensation-related genes.
Products Used: EpiNext High-Sensitivity Bisulfite-Seq Kit (Illumina), EpiNext NGS Barcode (Index) Set
Yin H et. al. (April 2024). Inhibition of METTL3 in macrophages provides protection against intestinal inflammation Cell Mol Immunol.
This study investigates the role of methyltransferase-like 3 (METTL3) in macrophages in the development of colitis. The researchers found that inhibiting METTL3 in macrophages protected mice against colitis by reprogramming glucose metabolism and suppressing CD4+ T helper 1 (Th1) cell differentiation, highlighting METTL3 as a potential therapeutic target for treating inflammatory bowel disease (IBD).
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Chen H et. al. (April 2024). Pre-eclamptic foetal programming predisposes offspring to hepatic steatosis via DNA methylation Biochim Biophys Acta Mol Basis Dis. :167189.
This study explores how pre-eclamptic fetal programming predisposes offspring to hepatic steatosis (fatty liver) via DNA methylation. Using a mouse model, researchers found that offspring from pre-eclamptic pregnancies exhibited increased weight gain, hepatic lipid accumulation, and impaired energy balance into adulthood, with epigenetic alterations in key genes related to lipid metabolism persisting from fetal stages to adulthood, suggesting a potential mechanism for the development of metabolic disorders in offspring exposed to maternal pre-eclampsia.
Products Used: MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit (Colorimetric)
Wu H et. al. (April 2024). MSC-derived exosomes deliver ZBTB4 to mediate transcriptional repression of ITIH3 in astrocytes in spinal cord injury Brain Res Bull. :110954.
This article examines the role of BMSC-derived exosomes in mediating transcriptional repression of ITIH3 in astrocytes following spinal cord injury (SCI). The researchers found that BMSC-Exos deliver ZBTB4, which represses ITIH3 expression, leading to improved motor function and reduced neuronal injury in SCI mice, suggesting a potential therapeutic mechanism for SCI treatment involving BMSC-Exos.
Products Used: FitAmp Blood and Cultured Cell DNA Extraction Kit
Zhou X et. al. (April 2024). Exposure to nicotine regulates prostaglandin E2 secretion and autophagy of granulosa cells to retard follicular maturation in mammals Ecotoxicol Environ Saf. 277:116358.
This study investigates how nicotine exposure affects follicular maturation in mammals by regulating prostaglandin E2 (PGE2) secretion and autophagy of granulosa cells (GCs). Nicotine was found to increase histone deacetylase 3 (HDAC3) expression, leading to apoptosis and autophagy of GCs, and inhibiting PGE2 secretion by suppressing cyclooxygenase 1 (COX1) expression, ultimately blocking follicular maturation. These findings suggest a potential molecular mechanism for the adverse effects of nicotine on female fertility and provide insights for potential therapeutic interventions.
Products Used: EpiQuik Chromatin Accessibility Assay Kit
Li F et. al. (April 2024). Comparative steroidogenic effects of hexafluoropropylene oxide trimer acid (HFPO-TA) and perfluorooctanoic acid (PFOA): Regulation of histone modifications Environ Pollut. :124030.
This study explores the comparative steroidogenic effects of hexafluoropropylene oxide trimer acid (HFPO-TA) and perfluorooctanoic acid (PFOA) on Leydig cells. HFPO-TA showed stronger effects on steroidogenesis compared to PFOA, possibly due to distinct regulation of histone modifications, suggesting HFPO-TA may not be a safer alternative to PFOA in terms of male reproductive toxicity.
Products Used: Histone H3K4me3 (H3K4 Trimethyl) Polyclonal Antibody
Ma W et. al. (April 2024). The histone lysine acetyltransferase KAT2B inhibits cholangiocarcinoma growth: evidence for interaction with SP1 to regulate NF2-YAP signaling J Exp Clin Cancer Res. 43(1):117.
This study investigates the role of the histone lysine acetyltransferase KAT2B in inhibiting cholangiocarcinoma (CCA) growth. KAT2B was found to be downregulated in human CCA, and its overexpression suppressed CCA cell proliferation and colony formation in vitro, as well as CCA growth in mice. Mechanistically, KAT2B enhanced the expression of the tumor suppressor gene NF2 by interacting with the transcription factor SP1, leading to inhibition of YAP activity and suggesting a potential therapeutic target for CCA treatment.
Products Used: EpiQuik Nuclear Extraction Kit
