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Loeb EJ et. al. (March 2024). Capsid-mediated control of adeno-associated viral transcription determines host range Cell Rep. 43(3):113902.
This study demonstrates that the capsid of adeno-associated virus (AAV) plays a crucial role in controlling viral transcription, determining its host range. By swapping specific components of the capsid, researchers were able to enhance viral transduction in human cells and mouse tissue, highlighting the importance of these interactions in AAV infection and potential gene therapy applications.
Products Used: EpiQuik Chromatin Accessibility Assay Kit
Chang M et. al. (March 2024). CsMYB73 negatively regulates theanine accumulation mediated by CsGGT2 and CsGGT4 in tea shoots (Camellia sinensis) Hortic Res. 11(3):uhae012.
The study investigates the transcriptional regulation of theanine metabolism in tea plants, focusing on the role of CsMYB73 in modulating the synthesis and degradation of theanine. CsGGT4, a γ-glutamyl-transpeptidase, is found to have higher theanine synthesis efficiency than CsGGT2, with CsMYB73 acting as an activator of CsGGT2 and a suppressor of CsGGT4, ultimately influencing theanine levels in tea shoots.
Products Used: EpiQuik Plant ChIP Kit
Cao Y et. al. (March 2024). N6-methyladenosine levels in peripheral blood RNA: a potential diagnostic biomarker for colorectal cancer Cancer Cell Int. 24(1):96.
This study explores the potential of N6-methyladenosine (m6A) levels in peripheral blood RNA as a diagnostic biomarker for colorectal cancer (CRC). The research indicates that m6A levels are elevated in CRC patients compared to healthy controls, with m6A showing a larger area under the curve (AUC) in diagnostic accuracy compared to traditional markers like carbohydrate antigen 199 (CA199) and carcinoembryonic antigen (CEA).
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Ma S et. al. (March 2024). MiR-186-5p prevents hepatocellular carcinoma progression by targeting methyltransferase-like 3 that regulates m6A-mediated stabilization of follistatin-like 5 Heliyon. 10(5):e26767.
The articles investigates the regulatory role of miR-186-5p in hepatocellular carcinoma (HCC) by targeting methyltransferase-like 3 (METTL3), which regulates m6A-mediated stabilization of follistatin-like 5 (FSTL5). The research demonstrates that miR-186-5p inhibits HCC progression by downregulating METTL3, leading to increased FSTL5 levels, suggesting a potential therapeutic target for HCC.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Cristian RE et. al. (March 2024). In Vivo Assessment of Hepatic and Kidney Toxicity Induced by Silicon Quantum Dots in Mice Nanomaterials (Basel). 14(5)
This study explores the hepatic and renal toxicity of silicon quantum dots (SiQDs) in mice, administered at different doses by intravenous injection. The results indicate that doses under 10 mg of SiQDs/kg of body weight do not induce toxicity in the liver and kidneys, providing valuable information for potential clinical applications of SiQDs.
Products Used: EpiQuik Total Histone Extraction Kit, EpiQuik Histone H4 Modification Multiplex Assay Kit (Colorimetric)
Osorio-Concepción M et. al. (March 2024). H3K4 methylation regulates development, DNA repair, and virulence in Mucorales IMA Fungus. 15(1):6.
This article investigates the role of H3K4 methylation in regulating development, DNA repair, and virulence in Mucorales, fungi that can cause mucormycosis. The research demonstrates that the histone methyltransferase Set1, responsible for H3K4 methylation, plays a crucial role in gene transcription activation, cell wall and DNA repair processes, and virulence, highlighting its potential as a therapeutic target against mucormycosis.
Products Used: Histone H3K4 Methylation Antibody Panel Pack
Ray D et. al. (February 2024). Screening H3 Histone Acetylation in a Wild Bird, the House Sparrow (Passer Domesticus) Integr Org Biol. 6(1):obae004.
This study investigates histone acetylation in wild birds, focusing on house sparrows (Passer domesticus) as a model organism. The research demonstrates high variance in histone acetylation among individuals, with differences correlated to epigenetic potential and gene expression, highlighting the importance of histone modification in ecologically relevant phenotypes.
Products Used: EpiQuik Total Histone H3 Acetylation Detection Fast Kit (Colorimetric), EpiQuik Total Histone Extraction Kit
Wu S et. al. (March 2024). Obesity-induced downregulation of miR-192 exacerbates lipopolysaccharide-induced acute lung injury by promoting macrophage activation Cell Mol Biol Lett. 29(1):36.
This article explores the role of miR-192 in obesity-induced acute lung injury (ALI) exacerbated by lipopolysaccharide (LPS) stimulation. The research shows that obesity downregulates miR-192 expression, leading to increased macrophage activation and exacerbation of ALI, suggesting that targeting miR-192 and macrophages could be a potential therapeutic approach for obesity-associated ALI.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Wei R et. al. (March 2024). The antagonistic effect of FTO on METTL14 promotes AKT3 m6A demethylation and the progression of esophageal cancer J Cancer Res Clin Oncol. 150(3):131.
The article investigates the interplay between the m6A demethylase FTO and the m6A methyltransferase METTL14 in esophageal cancer progression. The research shows that FTO, upregulated in esophageal cancer, promotes cancer cell proliferation and inhibits apoptosis, with METTL14 acting as an antagonist to FTO, suggesting a potential therapeutic target for esophageal cancer treatment.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Zhou L et. al. (February 2024). WTAP Mediated N6-methyladenosine RNA Modification of ELF3 Drives Cellular Senescence by Upregulating IRF8 Int J Biol Sci. 20(5):1763-1777.
This study explores the role of N6-methyladenosine (m6A) RNA modification in cellular senescence, focusing on the WTAP-ELF3-IRF8 axis in skin aging. The research shows that upregulation of Wilms' tumor 1-associating protein (WTAP) in aging skin tissues and senescent human dermal fibroblasts (HDFs) induces senescence by promoting the expression of ELF3 in an m6A-dependent manner, which in turn upregulates IRF8 and drives the senescence-associated secretory phenotype (SASP), suggesting a potential target for delaying skin aging.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Gao S et. al. (March 2024). Dynamics of N6-methyladenosine modification during Alzheimer's disease development Heliyon. 10(6):e26911.
This study investigates the dynamics of N6-methyladenosine (m6A) modification during Alzheimer's disease (AD) development, focusing on mRNA m6A modification and m6A enzyme expression profiles. The research reveals changes in m6A regulatory factors in early AD stages and significant differences in mRNA m6A modification between AD and control brains, suggesting a potential role for m6A modification in AD pathogenesis, particularly in microglia function and gene expression.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Cheng W et. al. (March 2024). Geniposide reduced oxidative stress-induced apoptosis in HK-2 cell through PI3K/AKT3/FOXO1 by m6A modification Int Immunopharmacol. 131:111820.
The article explores the protective effect of geniposide (GP) against oxidative stress-induced apoptosis in human kidney-2 (HK-2) cells and its potential mechanism involving N6-methyladenosine (m6A) RNA methylation. GP treatment alleviated H2O2-induced cell cycle arrest and apoptosis in HK-2 cells, associated with increased m6A RNA methylation levels and altered expression of PI3K/AKT3/FOXO1 signaling pathway components, suggesting a potential therapeutic strategy for kidney dysfunction related to oxidative stress.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
