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DNA Damage & Repair Antibodies

Cells undergo DNA damage constantly from exogenous and endogenous sources. Some of these sources include UV-light, ionizing radiation, alkylating agents and other environmental DNA damaging agents, as well as other sources derived spontaneously from cellular metabolism, such as reactive oxygen species. DNA damaging agents can cause a number of DNA lesions, including adducts, apurinic/apyrimidinic sites (AP sites), single-strand and double-strand DNA breaks. Left unrepaired, these DNA lesions could result in mutations, senescence, or induction of cell death which could lead to the development of neurodegeneration, cancer and other diseases.

In order to maintain genomic integrity, cells have developed the DNA damage response (DDR) pathway which allows cells to recognize the DNA damage and facilitate recruitment and activation of DNA repair proteins. Members of the phosphatidyl-inositol 3-kinase like protein kinase (PIKK) family, such as ATM, ATR and DNA-PK, are involved in this response, as well as a few members of the poly (ADP-ribose) polymerase (PARP) family.

Several DNA repair pathways exist to correct the DNA lesions depending on the particular form of DNA damage. For instance, the base excision repair (BER) and the mismatch repair (MMR) pathways mend damaged or mispaired DNA bases by excising the damaged base or by replacing mispaired bases with correct ones. Nucleotide excision repair (NER) fixes DNA lesions such as intrastrand crosslinks by removing a larger oligonucleotide DNA fragment; while double-strand breaks are generally repaired by non-homology end-joining (NHEJ) or by homology-directed repair (HDR).
Result Pages:  1  2  3  4  5 ...  [Next >>]  Displaying 1 to 20 (of 210 products)
Image Description Cat. No. Size Price
8-Hydroxyguanosine (8-OHG) Polyclonal Antibody
8-Hydroxyguanosine (8-OHG) Polyclonal Antibody

Application: ELISA, IH
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Goat
Isotype: IgG
Purification: Serum
Reactivity: Broad Range, Human, Mouse, Rat
A-6300-10.1 ml $421.00 Add to Cart
Antibodies
APEX1 Monoclonal Antibody [4D1]
APEX1 Monoclonal Antibody [4D1]

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG1 Kappa
Purification: Affinity Purified
Reactivity: Human
A-6101-100100 µg $452.00 Add to Cart
Antibodies
APEX1 Polyclonal Antibody
APEX1 Polyclonal Antibody

Application: ChIP, ELISA, IHC, WB
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human, Mouse
A68301-05050 µg $249.00 Add to Cart
A68301-100100 µg $349.00 Add to Cart
Antibodies
APEX1 Polyclonal Antibody, Biotin Conjugated
APEX1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A53393-05050 µg $249.00 Add to Cart
A53393-100100 µg $349.00 Add to Cart
Antibodies
APEX1 Polyclonal Antibody, FITC Conjugated
APEX1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A53394-05050 µg $249.00 Add to Cart
A53394-100100 µg $349.00 Add to Cart
Antibodies
APEX1 Polyclonal Antibody, HRP Conjugated
APEX1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A53395-05050 µg $249.00 Add to Cart
A53395-100100 µg $349.00 Add to Cart
Antibodies
ATM Monoclonal Antibody [2C10]
ATM Monoclonal Antibody [2C10]

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG2a Kappa
Purification: Affinity Purified
Reactivity: Human
A-6115-100100 µg $452.00 Add to Cart
Antibodies
ATR Monoclonal Antibody [3F2]
ATR Monoclonal Antibody [3F2]

Application: ELISA, IF, WB
Areas of Research: DNA Damage & Repair
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG1 Kappa
Purification: Affinity Purified
Reactivity: Human
A-6116-100100 µg $452.00 Add to Cart
Antibodies
ATRX Monoclonal Antibody [3C9]
ATRX Monoclonal Antibody [3C9]

Application: ELISA, WB
Areas of Research: DNA Damage & Repair
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG1 Kappa
Purification: Affinity Purified
Reactivity: Human
A-2113-100100 µg $452.00 Add to Cart
Antibodies
BRCA1 Polyclonal Antibody
BRCA1 Polyclonal Antibody

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A54101-05050 µg $249.00 Add to Cart
A54101-100100 µg $349.00 Add to Cart
Antibodies
BRCA1 Polyclonal Antibody, Biotin Conjugated
BRCA1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A54104-05050 µg $249.00 Add to Cart
A54104-100100 µg $349.00 Add to Cart
Antibodies
BRCA1 Polyclonal Antibody, FITC Conjugated
BRCA1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A54103-05050 µg $249.00 Add to Cart
A54103-100100 µg $349.00 Add to Cart
Antibodies
BRCA1 Polyclonal Antibody, HRP Conjugated
BRCA1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A54102-05050 µg $249.00 Add to Cart
A54102-100100 µg $349.00 Add to Cart
Antibodies
BRCA2 Monoclonal Antibody [3D12]
BRCA2 Monoclonal Antibody [3D12]

Application: ELISA, WB
Areas of Research: DNA Damage & Repair
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG3 Kappa
Purification: Affinity Purified
Reactivity: Human
A-6120-100100 µg $452.00 Add to Cart
Antibodies
BRCC3 Polyclonal Antibody
BRCC3 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A54460-05050 µg $249.00 Add to Cart
A54460-100100 µg $349.00 Add to Cart
Antibodies
BRCC3 Polyclonal Antibody, Biotin Conjugated
BRCC3 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A54461-05050 µg $249.00 Add to Cart
A54461-100100 µg $349.00 Add to Cart
Antibodies
BRCC3 Polyclonal Antibody, FITC Conjugated
BRCC3 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A54463-05050 µg $249.00 Add to Cart
A54463-100100 µg $349.00 Add to Cart
Antibodies
BRCC3 Polyclonal Antibody, HRP Conjugated
BRCC3 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A54462-05050 µg $249.00 Add to Cart
A54462-100100 µg $349.00 Add to Cart
Antibodies
CETN2 Polyclonal Antibody
CETN2 Polyclonal Antibody

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A54898-05050 µg $249.00 Add to Cart
A54898-100100 µg $349.00 Add to Cart
Antibodies
CETN2 Polyclonal Antibody, Biotin Conjugated
CETN2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A54895-05050 µg $249.00 Add to Cart
A54895-100100 µg $349.00 Add to Cart
Antibodies
Result Pages:  1  2  3  4  5 ...  [Next >>]  Displaying 1 to 20 (of 210 products)
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