Background SIRT2 is a member of the sirtuin (silent mating type information regulation 2 homolog) family of proteins which are characterized by a sirtuin core domain and are grouped into 4 class types. Sirtuins share NAD dependency for their enzymatic activity, but some show NAD-dependent deacetylase activity, while others exhibit ADP ribosyltransferase activity or both. Sirtuins may act to influence a wide range of cellular processes such as aging, transcription, apoptosis, inflammation and stress resistance. Seven members make up the family of sirtuins in mammals (SirT1-T7). SIRT2 is a Class I sirtuin.
DescriptionMouse monoclonal antibody raised against a partial recombinant SIRT2, clone 4B11.
Size100 µg
PurificationProtein A purified
ImmunogenSIRT2 (AAH03012, 128 a.a. ~ 227 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Cross ReactivityHuman
IsotypeIgG1 Kappa
FormulationIn 1x PBS, pH 7.2
StorageAliquot and store at -20ºC or lower. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance.
Handling RecommendationsFor maximum recovery of the products, centrifuge the vial prior to opening the cap.
Alternative NamesSirtuin2, FLJ35621 antibody, FLJ37491 antibody, NAD dependent deacetylase sirtuin 2 antibody, Regulatory protein SIR2 homolog 2 antibody, Silencing information regulator 2 like antibody, Silent mating type information regulation 2 antibody, SIR 2 antibody, SIR2L antibody, SIR2L2 antibody, Sirtuin 2 antibody
Applications & Suggested Dilutions*Western Blot: 0.5-1 µg/mlELISA: 0.25-1 µg/mlImmunofluorescence: 5 µg/ml