Core histone-binding subunit that may target chromatin assembly factors, chromatin remodeling factors and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the chromatin assembly factor 1 (CAF-1) complex, which is required for chromatin assembly following DNA replication and DNA repair; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
RBBP4 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Human, Mouse, Rat, Monkey
Recombinant Protein of Human RBBP4
Shipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.
WB, IHC, IF, IP