Histones are proteins found in eukaryotic cell nuclei that package and order the DNA into structural units called nucleosomes. Nucleosomes consist of about 146-147 bp of DNA wrapped around an octamer of histone proteins (histone 2A, histone 2B, histone 3, and histone 4). The N-terminal tails of histones protrude from the globular nucleosome core and can undergo several different types of epigenetic modifications that influence cellular processes. The interaction of linker histone, H1, with DNA between nucleosomes facilitates the compaction of chromatin into higher-order structures. Unlike most histone genes, this gene contains introns and its mRNA is polyadenylated. The protein encoded is a replication-independent member of the histone H3 family. Histone variant H3. 3 is typically enriched in active chromatin.
Phospho Histone H3.3 (Ser32) Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Liquid. PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Human, Mouse, Rat
Shipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.
WB; Recommended dilution: WB 1:500 - 1:2000