BackgroundTranscriptional activator which triggers apoptosis in the absence of survival factors, including neuronal cell death upon oxidative stress. Recognizes and binds to the DNA sequence 5'-[AG]TAAA[TC]A-3'. Participates in post-transcriptional regulation of MYC: following phosphorylation by MAPKAPK5, promotes induction of miR-34b and miR-34c expression, 2 post-transcriptional regulators of MYC that bind to the 3'UTR of MYC transcript and prevent its translation.
DescriptionPhospho FOXO3 (S253) Recombinant Monoclonal Antibody [1E1]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDO43524
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Phospho-FOXO3 (S253)
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesForkhead box protein O3, AF6q21 protein, FOXO3
ApplicationELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:50-1:200
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