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Introduction to Epigenetics

Phosphatase Antibodies

Phosphorylation is a major post-translational modification to proteins and controls cell signaling and induction of cell proliferation, differentiation, cell death and other biological processes. Phosphatases reverse phosphorylation by removing the phosphate group added by kinases mostly to serine, threonine or tyrosine residues in a protein. Thus phosphatases have a critical role in regulating cell signaling, as generally reversal of the phosphorylation indicates a switching off of the signal. Uncontrolled or constitutive signaling by cell surface receptors may lead to increased proliferation, among other outcomes, and could lead to the pathogenesis of cancer and other diseases. Therefore, after phosphorylation and protein activation by kinases, the signal must return to the resting or inactivated state through dephosphorylation catalyzed by phosphatases.

Two important phosphatases include the serine/threonine protein phosphatase 2A (PP2A) and phosphatase and tensin homolog (PTEN). PP2A is a key phosphatase as it catalyzes dephosphorylation of many proteins, but also dephosphorylates the main protein kinases responsible for activation of major signaling pathways, including AKT, ERK MAP kinase and Protein kinase C (PKC) family members. PTEN dephosphorylates proteins, as well as the phospholipid phosphatidylinositol (3,4,5)-trisphosphate (PIP3), which induces inhibition of signaling by AKT, a critical pathway involved in cellular growth and proliferation. PTEN is a tumor suppressor frequently mutated and involved in the pathogenesis and progression of several cancers.
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MTMR6 Polyclonal Antibody
MTMR6 Polyclonal Antibody

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A59954-02020 µg $59.00 Add to Cart
A59954-05050 µg $256.00 Add to Cart
A59954-100100 µg $359.00 Add to Cart
Antibodies
MTMR6 Polyclonal Antibody, Biotin Conjugated
MTMR6 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A59955-05050 µg $256.00 Add to Cart
A59955-100100 µg $359.00 Add to Cart
Antibodies
MTMR6 Polyclonal Antibody, FITC Conjugated
MTMR6 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A59956-05050 µg $256.00 Add to Cart
A59956-100100 µg $359.00 Add to Cart
Antibodies
MTMR6 Polyclonal Antibody, HRP Conjugated
MTMR6 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A59957-05050 µg $256.00 Add to Cart
A59957-100100 µg $359.00 Add to Cart
Antibodies
MTMR7 Polyclonal Antibody
MTMR7 Polyclonal Antibody

Application: ELISA, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human, Mouse
Trial Size Available: Yes
A56531-02020 µg $59.00 Add to Cart
A56531-05050 µg $256.00 Add to Cart
A56531-100100 µg $359.00 Add to Cart
Antibodies
MTMR7 Polyclonal Antibody, Biotin Conjugated
MTMR7 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A56534-05050 µg $256.00 Add to Cart
A56534-100100 µg $359.00 Add to Cart
Antibodies
MTMR7 Polyclonal Antibody, FITC Conjugated
MTMR7 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A56533-05050 µg $256.00 Add to Cart
A56533-100100 µg $359.00 Add to Cart
Antibodies
MTMR7 Polyclonal Antibody, HRP Conjugated
MTMR7 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A56532-05050 µg $256.00 Add to Cart
A56532-100100 µg $359.00 Add to Cart
Antibodies
MVD Polyclonal Antibody
MVD Polyclonal Antibody

Application: ELISA, IF, IHC, WB
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human, Rat
Trial Size Available: Yes
A69603-02020 µg $59.00 Add to Cart
A69603-05050 µg $249.00 Add to Cart
A69603-100100 µg $399.00 Add to Cart
Antibodies
MVD Polyclonal Antibody, Biotin Conjugated
MVD Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69606-05050 µg $249.00 Add to Cart
A69606-100100 µg $399.00 Add to Cart
Antibodies
MVD Polyclonal Antibody, FITC Conjugated
MVD Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69605-05050 µg $249.00 Add to Cart
A69605-100100 µg $399.00 Add to Cart
Antibodies
MVD Polyclonal Antibody, HRP Conjugated
MVD Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A69604-05050 µg $249.00 Add to Cart
A69604-100100 µg $399.00 Add to Cart
Antibodies
PLPPR2 Polyclonal Antibody
PLPPR2 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A57489-05050 µg $256.00 Add to Cart
A57489-100100 µg $359.00 Add to Cart
Antibodies
PLPPR2 Polyclonal Antibody, Biotin Conjugated
PLPPR2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A57492-05050 µg $256.00 Add to Cart
A57492-100100 µg $359.00 Add to Cart
Antibodies
PLPPR2 Polyclonal Antibody, FITC Conjugated
PLPPR2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A57491-05050 µg $256.00 Add to Cart
A57491-100100 µg $359.00 Add to Cart
Antibodies
PLPPR2 Polyclonal Antibody, HRP Conjugated
PLPPR2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Signal Transduction
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Caprylic Acid Ammonium Sulfate Precipitation purified
Reactivity: Human
A57490-05050 µg $256.00 Add to Cart
A57490-100100 µg $359.00 Add to Cart
Antibodies
PPEF1 Polyclonal Antibody
PPEF1 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human, Mouse
Trial Size Available: Yes
A60366-02020 µg $59.00 Add to Cart
A60366-05050 µg $256.00 Add to Cart
A60366-100100 µg $359.00 Add to Cart
Antibodies
PPEF1 Polyclonal Antibody, Biotin Conjugated
PPEF1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A60367-05050 µg $256.00 Add to Cart
A60367-100100 µg $359.00 Add to Cart
Antibodies
PPEF1 Polyclonal Antibody, FITC Conjugated
PPEF1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A60368-05050 µg $256.00 Add to Cart
A60368-100100 µg $359.00 Add to Cart
Antibodies
PPEF1 Polyclonal Antibody, HRP Conjugated
PPEF1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A60369-05050 µg $256.00 Add to Cart
A60369-100100 µg $359.00 Add to Cart
Antibodies
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