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Phosphatase Antibodies
Phosphorylation is a major post-translational modification to proteins and controls cell signaling and induction of cell proliferation, differentiation, cell death and other biological processes. Phosphatases reverse phosphorylation by removing the phosphate group added by kinases mostly to serine, threonine or tyrosine residues in a protein. Thus phosphatases have a critical role in regulating cell signaling, as generally reversal of the phosphorylation indicates a switching off of the signal. Uncontrolled or constitutive signaling by cell surface receptors may lead to increased proliferation, among other outcomes, and could lead to the pathogenesis of cancer and other diseases. Therefore, after phosphorylation and protein activation by kinases, the signal must return to the resting or inactivated state through dephosphorylation catalyzed by phosphatases.
Two important phosphatases include the serine/threonine protein phosphatase 2A (PP2A) and phosphatase and tensin homolog (PTEN). PP2A is a key phosphatase as it catalyzes dephosphorylation of many proteins, but also dephosphorylates the main protein kinases responsible for activation of major signaling pathways, including AKT, ERK MAP kinase and Protein kinase C (PKC) family members. PTEN dephosphorylates proteins, as well as the phospholipid phosphatidylinositol (3,4,5)-trisphosphate (PIP3), which induces inhibition of signaling by AKT, a critical pathway involved in cellular growth and proliferation. PTEN is a tumor suppressor frequently mutated and involved in the pathogenesis and progression of several cancers. |
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| Result Pages: 2 |
Displaying 21 to 40 (of 182 products) |
ILKAP Polyclonal Antibody
| Application: |
ELISA, WB |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
Unconjugated |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human, Mouse, Rat |
| Trial Size Available: |
Yes |
| A54596-020 | 20 µg | $99.00 |  |
| A54596-050 | 50 µg | $256.00 | |
| A54596-100 | 100 µg | $359.00 | |
| A54593-050 | 50 µg | $256.00 | |
| A54593-100 | 100 µg | $359.00 | |
ILKAP Polyclonal Antibody, FITC Conjugated
| Application: |
ELISA |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
FITC |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A54594-050 | 50 µg | $256.00 | |
| A54594-100 | 100 µg | $359.00 | |
ILKAP Polyclonal Antibody, HRP Conjugated
| Application: |
ELISA |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
HRP |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A54595-050 | 50 µg | $256.00 | |
| A54595-100 | 100 µg | $359.00 | |
INPP1 Polyclonal Antibody
| Application: |
ELISA, IHC |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
Unconjugated |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| Trial Size Available: |
Yes |
| A59482-020 | 20 µg | $99.00 | |
| A59482-050 | 50 µg | $256.00 | |
| A59482-100 | 100 µg | $359.00 | |
| A59483-050 | 50 µg | $256.00 | |
| A59483-100 | 100 µg | $359.00 | |
INPP1 Polyclonal Antibody, FITC Conjugated
| Application: |
ELISA |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
FITC |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A59484-050 | 50 µg | $256.00 | |
| A59484-100 | 100 µg | $359.00 | |
INPP1 Polyclonal Antibody, HRP Conjugated
| Application: |
ELISA |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
HRP |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A59485-050 | 50 µg | $256.00 | |
| A59485-100 | 100 µg | $359.00 | |
INPP5A Polyclonal Antibody
| Application: |
ELISA, IF, IHC |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
Unconjugated |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| Trial Size Available: |
Yes |
| A55251-020 | 20 µg | $99.00 | |
| A55251-050 | 50 µg | $256.00 | |
| A55251-100 | 100 µg | $359.00 | |
| A55254-050 | 50 µg | $256.00 | |
| A55254-100 | 100 µg | $359.00 | |
INPP5A Polyclonal Antibody, FITC Conjugated
| Application: |
ELISA |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
FITC |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A55253-050 | 50 µg | $256.00 | |
| A55253-100 | 100 µg | $359.00 | |
INPP5A Polyclonal Antibody, HRP Conjugated
| Application: |
ELISA |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
HRP |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A55252-050 | 50 µg | $256.00 | |
| A55252-100 | 100 µg | $359.00 | |
INPP5B Polyclonal Antibody
| Application: |
ELISA, IF, IHC |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
Unconjugated |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| Trial Size Available: |
Yes |
| A69555-020 | 20 µg | $99.00 | |
| A69555-050 | 50 µg | $249.00 | |
| A69555-100 | 100 µg | $399.00 | |
| A69558-050 | 50 µg | $249.00 | |
| A69558-100 | 100 µg | $399.00 | |
INPP5B Polyclonal Antibody, FITC Conjugated
| Application: |
ELISA |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
FITC |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A69557-050 | 50 µg | $249.00 | |
| A69557-100 | 100 µg | $399.00 | |
INPP5B Polyclonal Antibody, HRP Conjugated
| Application: |
ELISA |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
HRP |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A69556-050 | 50 µg | $249.00 | |
| A69556-100 | 100 µg | $399.00 | |
MTMR11 Polyclonal Antibody
| Application: |
ELISA |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
Unconjugated |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| Trial Size Available: |
Yes |
| A62990-020 | 20 µg | $99.00 | |
| A62990-050 | 50 µg | $256.00 | |
| A62990-100 | 100 µg | $359.00 | |
| A62993-050 | 50 µg | $256.00 | |
| A62993-100 | 100 µg | $359.00 | |
MTMR11 Polyclonal Antibody, FITC Conjugated
| Application: |
ELISA |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
FITC |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A62992-050 | 50 µg | $256.00 | |
| A62992-100 | 100 µg | $359.00 | |
MTMR11 Polyclonal Antibody, HRP Conjugated
| Application: |
ELISA |
| Areas of Research: |
Signal Transduction |
| Clonality: |
Polyclonal |
| Conjugate: |
HRP |
| Host: |
Rabbit |
| Isotype: |
IgG |
| Purification: |
Protein G Purified |
| Reactivity: |
Human |
| A62991-050 | 50 µg | $256.00 | |
| A62991-100 | 100 µg | $359.00 | |
| Result Pages: 2 |
Displaying 21 to 40 (of 182 products) |
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Home » Antibodies » Primary Antibodies » Signal Transduction Antibodies » Phosphatase Antibodies 
