MSH6 Polyclonal Antibody

Background
MSH6 (mutS homolog 6)is a DNA mismatch repair protein and a member of the Mutator S (MutS) family of proteins that are involved in DNA damage repair. Together, MSH2 and MSH6 form the hMutS-alpha dimer which is an essential component of the mismatch repair process. This component is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins, and the Rad50-Mre11-NBS1 complex. Defects in human MSH6 and other MMR proteins have been found in hereditary nonpolyposis colorectal cancer (Lynch Syndrome), a common form of inherited colorectal cancer.

Description
MSH6 Polyclonal Antibody . Unconjugated. Raised in: Rabbit.

Formulation
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Specificity
Human, Mouse, Rat, Monkey

Isotype
IgG

Uniprot ID
P52701

Purification
Affinity Purification

Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-290 of human MSH6 (NP_000170.1).

Storage
Shipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles

Alternative Names
GTBP, HNPCC5, HSAP

Application
WB, IHC, IF; Recommended dilution: WB: 1:500-1:2000, IHC: 1:50-1:200, IF:1:20-1:100