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MSH6 Polyclonal Antibody

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Immunohistochemistry of paraffin-embedded human amygdalitis using MSH6 Polyclonal Antibody at dilution of 1:100 (400x lens).
Immunofluorescence analysis of A549 cell using MSH6 Polyclonal Antibody.
Immunofluorescence analysis of GFP-RNF168 transgenic U2OS cell using MSH6 Polyclonal Antibody. Green: GFP-RNF168 fusion protein expression for DNA damage marker. Blue: DAPI for nuclear staining. RNF168(GFP) can be used to mark cells damaged by UV-A laser for they always gather around DNA damage region.
Immunofluorescence analysis of HeLa cell using MSH6 Polyclonal Antibody. Blue: DAPI for nuclear staining.
Western blot analysis of extracts of various cell lines, using MSH6 Polyclonal Antibody.
Immunohistochemistry of paraffin-embedded human lung cancer using MSH6 Polyclonal Antibody at dilution of 1:100 (400x lens).
Immunohistochemistry of paraffin-embedded human colon using MSH6 Polyclonal Antibody at dilution of 1:100 (400x lens).
Immunohistochemistry of paraffin-embedded human oophoroma using MSH6 Polyclonal Antibody at dilution of 1:100 (400x lens).
Immunohistochemistry of paraffin-embedded human kidney cancer using MSH6 Polyclonal Antibody at dilution of 1:100 (400x lens).
Application: IF, IHC, WB
Areas of Research: DNA Damage & Repair
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Monkey, Mouse
100% Guarantee: 6 months
Catalog No.SizePriceQty
A-6702-05050 µl $189.00 
A-6702-100100 µl $299.00 
Availability: Usually Ships in 3-4 Days 
Product Overview

Background
MSH6 (mutS homolog 6)is a DNA mismatch repair protein and a member of the Mutator S (MutS) family of proteins that are involved in DNA damage repair. Together, MSH2 and MSH6 form the hMutS-alpha dimer which is an essential component of the mismatch repair process. This component is part of the BRCA1-associated surveillance complex (BASC), a complex that also contains BRCA1, MLH1, ATM, BLM, PMS2 proteins, and the Rad50-Mre11-NBS1 complex. Defects in human MSH6 and other MMR proteins have been found in hereditary nonpolyposis colorectal cancer (Lynch Syndrome), a common form of inherited colorectal cancer.

Description
MSH6 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Formulation
Liquid. PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Specificity
Human, Mouse, Monkey

Isotype
IgG

Uniprot ID
P52701

Purification
Affinity Purified

Immunogen
Recombinant Protein of Human MSH6

Storage
Shipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.

Alternative Names
GTBP, HNPCC5, HSAP

Application
WB, IHC, IF; Recommended dilution: WB 1:500 - 1:2000, IHC 1:50 - 1:200, IF 1:20 - 1:100

User Guide & MSDS

[User Guide]*
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