Background MBD5, or methyl-CpG binding domain protein 5, is a part of the methyl-CpG-binding domain (MBD) family, which also includes MeCP2, MBD1, MBD2, MBD3, MBD4, CLLD8-like, and BAZ2A-like proteins. This protein contains a Pro-Trp-Trp-Pro motif (PWWP) domain as well as the MBD domain. The proteins of the PWWP domain play a role in cell division, cell growth, and cell differentiation. Evidence shows that diseases, such as mental retardation autosomal dominant type 1, can be caused by mutation to the MBD5 gene and some research indicates it may be involved in neurodevelopmental disorders and postnatal growth of mice.
DescriptionMouse monoclonal antibody raised against a full length recombinant MBD5, clone 4A12-1B6.Size100 µgPurificationProtein A purified
ImmunogenMBD5 (AAH14534, 1 a.a. ~ 291 a.a) full length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Cross ReactivityHuman
IsotypeIgG1 Kappa
FormulationIn 1x PBS, pH 7.2
StorageAliquot and store at -20ºC or lower. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance.
Handling RecommendationsFor maximum recovery of the products, centrifuge the vial prior to opening the cap.
Alternative NamesAUTSX 3 antibody, DKFZp686A24160 antibody, Mbd 5 antibody, MECP 2 antibody, MeCP 2 protein antibody, MECP2_HUMAN antibody, Methyl CpG binding protein 2 (Rett syndrome) antibody, MRX 16 antibody, MRX 79 antibody, MRXS 13 antibody, MRXSL antibody, PPMX antibody, RS antibody, RTS antibody, RTT antibody, WBP 10 antibody
Applications & Suggested Dilutions*Western Blot: 0.5-1 μg/mlELISA: 0.25-1 µg/ml
*The end user is responsible for determining optimal working dilutions.
Quality ControlWestern Blot detection against Immunogen (51.3 KDa).
Note: This item was formerly catalog no. ABB-1015 (ABB1015)
Applications