HSPA8 Recombinant Monoclonal Antibody [3G10]

Background
This chaperone has numerous roles: safeguarding proteins from stress, aiding folding, activating degradation of misfolded proteins, and assisting in protein complex assembly. It ensures proper folding, guided by co-chaperones. ATP cycles regulate its binding to substrates. Co-chaperones include HSP40s (ATPase stimulation), NEFs (promote substrate release), and TPR domain chaperones. It inhibits transcriptional activation, aids in splicing, interacts with bacterial lipopolysaccharide, and participates in ER-associated protein degradation (ERAD) with STUB1.

Description
HSPA8 Recombinant Monoclonal Antibody [3G10]. Unconjugated. Raised in: HEK293F Cell.

Formulation
Buffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Specificity
Human

Isotype
Rabbit IgG

Uniprot ID
P11142

Purification
Affinity Chromatography

Immunogen
A synthesized peptide derived from human HSPA8

Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Alternative Names
Heat shock cognate 71 kDa protein, Heat shock 70 kDa protein 8, Lipopolysaccharide-associated protein 1, LAP-1, LPS-associated protein 1, HSPA8, HSC70, HSP73, HSPA10

Application
ELISA, WB; Recommended dilution: WB:1:500-1:5000