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Histone Modification Antibodies

Histone modification antibodies are used to investigate epigenetic modifications to histones such as acetylation, methylation, and phosphorylation. Histone methylation is associated with transcriptional repression or activation via the transfer of methyl groups to lysine or arginine residues of histone proteins and is crucial to studying epigenetic gene regulation with the use of histone methylation antibodies. Histone methyltransferases (HMTs) are responsible for catalyzing this process. Similarly, histone acetylation antibodies can be used to study chromatin remodeling and epigenetic gene regulation that occurs as a result of histone acetylation. This histone modification is defined as the addition of an acetyl group to lysine residues of histone proteins by enzymes known as histone acetyltransferases (HATs), and is associated with gene activation and expression.

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Histone Methylation (Lysine) Antibodies
Histone lysine methylation is a well-established transcriptional mechanism for regulating gene expression in eukaryotic cells. Histone N-terminal tails are susceptible to post-translational modifications (PTMs) and can influence many biological processes including transcription, replication, and chromosome maintenance. Methylation of lysine residues within histones is tightly regulated by methyltransferases (KMTs) and demethylases (KDMs) to preserve cell fate and genomic stability.

Histone Methylation (Arginine) Antibodies
Arginine methylation is a broadly expressed post-translational modification that occurs on both nuclear and cytoplasmic proteins. It is especially profuse on proteins that can shuttle continuously between the nucleus and the cytoplasm. The family of protein arginine methyltransferases (PRMTs) catalyzes methylation reactions, including target histones. Histone arginine methylation, which transpires on the tails of histone, can encourage or prevent the docking of key transcriptional effector molecules, thus making it a key contributor of the histone code.

Other Histone Methylation Antibodies
Histone methylation occurs with the addition of a methyl group to the amino-terminal tails of histone proteins. Depending on how many methyl groups are added and which amino acid residue is modified, histone methylation can have a positive or negative effect on gene transcription. Histone methyltransferases (HMTs) are enzymes that catalyze the addition of methyl groups to histone proteins, while histone demethylases (HDMs) remove these methyl groups. This process is important for regulating gene expression which allows different cells to express different genes.

Histone Acetylation Antibodies
Histone acetylation is defined by the addition of an acetyl functional group to the lysine residues of the N-terminal tail and its status can be studied with the use of histone acetylation antibodies. Evidence shows histone acetylation is highly involved in gene regulation and histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity affect the availability of chromatin to gene transcription.

Histone Deacetylation Antibodies
Histone deacetylation, the process by which histone deacetylase (HDAC) catalyzes the removal of the acetyl functional group from histones, can be investigated using HDAC antibodies. Decreased levels of acetylation as a result of HDAC activity has been linked to repression of gene expression due to the condensed state of chromatin, referred to as heterochromatin.

Other Histone Acetylation Antibodies
The process of histone acetylation at lysine residues by histone acetyltransferase (HAT) is an important epigenetic marker and can be measured with the use of histone lysine acetylation antibodies. Acetylation of histones reduces the interaction of histone N termini with the phosphate groups of DNA, thereby loosening chromatin and opening it up for increased gene transcription. Acetylation of H3K14, for instance, has been linked to transcriptional activation and specifically DNA repair.

Histone Phosphorylation Antibodies
Antibodies that detect phosphorylated target proteins help researchers to understand the role phosphorylation plays in cellular processes. Phosphorylation can turn on and off numerous protein enzymes by adding a phosphate group to the protein, thereby affecting their activity and function.

Ubiquitination & SUMOylation Antibodies
Ubiquitination is the process by which ubiquitin is attached to a substrate protein after it has been made. It has been known to affect proteins by altering cellular location, impacting protein activity, and adjusting protein-protein interactions. Research shows that sumoylation regulates protein-protein interactions and subcellular targeting and is involved in numerous processes such as nuclear-cytosolic transport, apoptosis, transcriptional regulation, response to stress, protein stability, and progression through the cell cycle. Ubiquitination antibodies and sumoylation antibodies are a useful tool to researchers investigating the control mechanisms associated with numerous nuclear proteins.

Other Histone Antibodies
Other histone antibodies can be used to study the core nucleosomal histones, the histones regularly associated with DNA in chromatin, as well as non-canonical histone variants that often can substitute for the core histones under diverse physiological and environmental conditions. The core nucleosomal histones are mostly incorporated into chromatin during DNA replication, while histone variants can be integrated throughout the cell cycle. Adjoining of these histone variants can alter chromatin structure and affect transcription, DNA replication and other biological processes, and can influence embryonic development and cell fate decisions. Some well-known histone variants include H2A.X, H2A.Z and H3.3.

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DCAF4 Polyclonal Antibody, FITC Conjugated
DCAF4 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A51191-05050 µg $256.00 Add to Cart
A51191-100100 µg $359.00 Add to Cart
Antibodies
DCAF4 Polyclonal Antibody, HRP Conjugated
DCAF4 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A51190-05050 µg $256.00 Add to Cart
A51190-100100 µg $359.00 Add to Cart
Antibodies
DCUN1D1 Polyclonal Antibody
DCUN1D1 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A56455-02020 µg $99.00 Add to Cart
A56455-05050 µg $256.00 Add to Cart
A56455-100100 µg $359.00 Add to Cart
Antibodies
DCUN1D1 Polyclonal Antibody
DCUN1D1 Polyclonal Antibody new product

Application: WB
Areas of Research: Ubiquitination & SUMOylation Antibodies
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse
Trial Size Available: A71716-020
A71716-05050 µl $256.00 Add to Cart
A71716-100100 µl $359.00 Add to Cart
Antibodies
DCUN1D1 Polyclonal Antibody, Biotin Conjugated
DCUN1D1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A56458-05050 µg $256.00 Add to Cart
A56458-100100 µg $359.00 Add to Cart
Antibodies
DCUN1D1 Polyclonal Antibody, FITC Conjugated
DCUN1D1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A56457-05050 µg $256.00 Add to Cart
A56457-100100 µg $359.00 Add to Cart
Antibodies
DCUN1D1 Polyclonal Antibody, HRP Conjugated
DCUN1D1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A56456-05050 µg $256.00 Add to Cart
A56456-100100 µg $359.00 Add to Cart
Antibodies
DCUN1D2 Polyclonal Antibody
DCUN1D2 Polyclonal Antibody

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A65586-02020 µg $99.00 Add to Cart
A65586-05050 µg $256.00 Add to Cart
A65586-100100 µg $359.00 Add to Cart
Antibodies
DCUN1D2 Polyclonal Antibody, Biotin Conjugated
DCUN1D2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A65589-05050 µg $256.00 Add to Cart
A65589-100100 µg $359.00 Add to Cart
Antibodies
DCUN1D2 Polyclonal Antibody, FITC Conjugated
DCUN1D2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A65588-05050 µg $256.00 Add to Cart
A65588-100100 µg $359.00 Add to Cart
Antibodies
DCUN1D2 Polyclonal Antibody, HRP Conjugated
DCUN1D2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A65587-05050 µg $256.00 Add to Cart
A65587-100100 µg $359.00 Add to Cart
Antibodies
DPY30 Polyclonal Antibody
DPY30 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Histone Methylation & Demethylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A58846-02020 µg $99.00 Add to Cart
A58846-05050 µg $256.00 Add to Cart
A58846-100100 µg $359.00 Add to Cart
Antibodies
DPY30 Polyclonal Antibody, Biotin Conjugated
DPY30 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Histone Methylation & Demethylation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A58847-05050 µg $256.00 Add to Cart
A58847-100100 µg $359.00 Add to Cart
Antibodies
DPY30 Polyclonal Antibody, FITC Conjugated
DPY30 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Histone Methylation & Demethylation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A58848-05050 µg $256.00 Add to Cart
A58848-100100 µg $359.00 Add to Cart
Antibodies
DPY30 Polyclonal Antibody, HRP Conjugated
DPY30 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Histone Methylation & Demethylation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A58849-05050 µg $256.00 Add to Cart
A58849-100100 µg $359.00 Add to Cart
Antibodies
EHMT2 Polyclonal Antibody
EHMT2 Polyclonal Antibody

Application: IF, WB
Areas of Research: Histone Methylation & Demethylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse, Rat
A-3019-05050 µl $199.00 Add to Cart
A-3019-100100 µl $391.00 Add to Cart
Antibodies
ELP3 Polyclonal Antibody
ELP3 Polyclonal Antibody new product

Application: IHC, WB
Areas of Research: Histone Acetylation Antibodies
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse, Rat
Trial Size Available: A73063-020
A73063-05050 µl $256.00 Add to Cart
A73063-100100 µl $359.00 Add to Cart
Antibodies
ELP3 Polyclonal Antibody
ELP3 Polyclonal Antibody

Application: ELISA, IF, IHC, IP, WB
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A69279-02020 µg $99.00 Add to Cart
A69279-05050 µg $249.00 Add to Cart
A69279-100100 µg $399.00 Add to Cart
Antibodies
ELP3 Polyclonal Antibody, Biotin Conjugated
ELP3 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69282-05050 µg $249.00 Add to Cart
A69282-100100 µg $399.00 Add to Cart
Antibodies
ELP3 Polyclonal Antibody, FITC Conjugated
ELP3 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69281-05050 µg $249.00 Add to Cart
A69281-100100 µg $399.00 Add to Cart
Antibodies
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