Epigentek Home
 
EpiGentek Guarantee
Refine Your Results
Introduction to Epigenetics
Histone Modification Antibodies

Histone Modification Antibodies

Histone modification antibodies are used to investigate epigenetic modifications to histones such as acetylation, methylation, and phosphorylation. Histone methylation is associated with transcriptional repression or activation via the transfer of methyl groups to lysine or arginine residues of histone proteins and is crucial to studying epigenetic gene regulation with the use of histone methylation antibodies. Histone methyltransferases (HMTs) are responsible for catalyzing this process. Similarly, histone acetylation antibodies can be used to study chromatin remodeling and epigenetic gene regulation that occurs as a result of histone acetylation. This histone modification is defined as the addition of an acetyl group to lysine residues of histone proteins by enzymes known as histone acetyltransferases (HATs), and is associated with gene activation and expression.
Histone Methylation (Lysine) Antibodies
Histone lysine methylation is a well-established transcriptional mechanism for regulating gene expression in eukaryotic cells. Histone N-terminal tails are susceptible to post-translational modifications (PTMs) and can influence many biological processes including transcription, replication, and chromosome maintenance. Methylation of lysine residues within histones is tightly regulated by methyltransferases (KMTs) and demethylases (KDMs) to preserve cell fate and genomic stability.

Histone Methylation (Arginine) Antibodies
Arginine methylation is a broadly expressed post-translational modification that occurs on both nuclear and cytoplasmic proteins. It is especially profuse on proteins that can shuttle continuously between the nucleus and the cytoplasm. The family of protein arginine methyltransferases (PRMTs) catalyzes methylation reactions, including target histones. Histone arginine methylation, which transpires on the tails of histone, can encourage or prevent the docking of key transcriptional effe...

Other Histone Methylation Antibodies
Histone methylation occurs with the addition of a methyl group to the amino-terminal tails of histone proteins. Depending on how many methyl groups are added and which amino acid residue is modified, histone methylation can have a positive or negative effect on gene transcription. Histone methyltransferases (HMTs) are enzymes that catalyze the addition of methyl groups to histone proteins, while histone demethylases (HDMs) remove these methyl groups. This process is important f...

Histone Acetylation Antibodies
Histone acetylation is defined by the addition of an acetyl functional group to the lysine residues of the N-terminal tail and its status can be studied with the use of histone acetylation antibodies. Evidence shows histone acetylation is highly involved in gene regulation and histone acetyltransferase (HAT) and histone deacetylase (HDAC) activity affect the availability of chromatin to gene transcription.

Histone Deacetylation Antibodies
Histone deacetylation, the process by which histone deacetylase (HDAC) catalyzes the removal of the acetyl functional group from histones, can be investigated using HDAC antibodies. Decreased levels of acetylation as a result of HDAC activity has been linked to repression of gene expression due to the condensed state of chromatin, referred to as heterochromatin.

Other Histone Acetylation Antibodies
The process of histone acetylation at lysine residues by histone acetyltransferase (HAT) is an important epigenetic marker and can be measured with the use of histone lysine acetylation antibodies. Acetylation of histones reduces the interaction of histone N termini with the phosphate groups of DNA, thereby loosening chromatin and opening it up for increased gene transcription. Acetylation of H3K14, for instance, has been linked to transcriptional activation and specifically DNA repair...

Histone Phosphorylation Antibodies
Antibodies that detect phosphorylated target proteins help researchers to understand the role phosphorylation plays in cellular processes. Phosphorylation can turn on and off numerous protein enzymes by adding a phosphate group to the protein, thereby affecting their activity and function.

Ubiquitination & SUMOylation Antibodies
Ubiquitination is the process by which ubiquitin is attached to a substrate protein after it has been made. It has been known to affect proteins by altering cellular location, impacting protein activity, and adjusting protein-protein interactions. Research shows that sumoylation regulates protein-protein interactions and subcellular targeting and is involved in numerous processes such as nuclear-cytosolic transport, apoptosis, transcriptional regulation, response to stress, protein stability,...

Other Histone Antibodies
Other histone antibodies can be used to study the core nucleosomal histones, the histones regularly associated with DNA in chromatin, as well as non-canonical histone variants that often can substitute for the core histones under diverse physiological and environmental conditions. The core nucleosomal histones are mostly incorporated into chromatin during DNA replication, while histone variants can be integrated throughout the cell cycle. Adjoining of these histone variants can alter chromatin structure and affect transcription, DNA replication and other biological processes, and can influence embryonic development and cell fate decisions. Some well-known histone variants include H2A.X, H2A.Z and H3.3.

Result Pages: [<< Prev]  ... 6  7  8  9  10 ...  [Next >>]  Displaying 181 to 200 (of 1189 products)
H2AFB1 Polyclonal Antibody, HRP Conjugated
H2AFB1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Unmodified Histone
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A62727-05050 µg $256.00 Add to Cart
A62727-100100 µg $359.00 Add to Cart
Antibodies
H2AFV Polyclonal Antibody
H2AFV Polyclonal Antibody

Application: ELISA
Areas of Research: Unmodified Histone
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A64060-02020 µg $59.00 Add to Cart
A64060-05050 µg $256.00 Add to Cart
A64060-100100 µg $359.00 Add to Cart
Antibodies
H2AFV Polyclonal Antibody, Biotin Conjugated
H2AFV Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Unmodified Histone
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A64063-05050 µg $256.00 Add to Cart
A64063-100100 µg $359.00 Add to Cart
Antibodies
H2AFV Polyclonal Antibody, FITC Conjugated
H2AFV Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Unmodified Histone
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A64062-05050 µg $256.00 Add to Cart
A64062-100100 µg $359.00 Add to Cart
Antibodies
H2AFV Polyclonal Antibody, HRP Conjugated
H2AFV Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Unmodified Histone
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A64061-05050 µg $256.00 Add to Cart
A64061-100100 µg $359.00 Add to Cart
Antibodies
H2AFY2 Polyclonal Antibody
H2AFY2 Polyclonal Antibody

Application: ELISA
Areas of Research: Unmodified Histone
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A67878-02020 µg $59.00 Add to Cart
A67878-05050 µg $256.00 Add to Cart
A67878-100100 µg $359.00 Add to Cart
Antibodies
H2AFY2 Polyclonal Antibody, Biotin Conjugated
H2AFY2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Unmodified Histone
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67881-05050 µg $256.00 Add to Cart
A67881-100100 µg $359.00 Add to Cart
Antibodies
H2AFY2 Polyclonal Antibody, FITC Conjugated
H2AFY2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Unmodified Histone
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67880-05050 µg $256.00 Add to Cart
A67880-100100 µg $359.00 Add to Cart
Antibodies
H2AFY2 Polyclonal Antibody, HRP Conjugated
H2AFY2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Unmodified Histone
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67879-05050 µg $256.00 Add to Cart
A67879-100100 µg $359.00 Add to Cart
Antibodies
H2AX Polyclonal Antibody
H2AX Polyclonal Antibody

Application: ICC, IHC, WB
Areas of Research: Unmodified Histone
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse, Rat
A-7701-05050 µl $299.00 Add to Cart
A-7701-100100 µl $550.00 Add to Cart
Antibodies
H3F3A (Ab-79) Polyclonal Antibody
H3F3A (Ab-79) Polyclonal Antibody

Application: ChIP, ELISA, WB
Areas of Research: Histone Modification
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Rat
A70375-05050 µl $249.00 Add to Cart
A70375-100100 µl $399.00 Add to Cart
Antibodies
H3F3A (K79) Dimethyl Polyclonal Antibody
H3F3A (K79) Dimethyl Polyclonal Antibody

Application: ELISA, WB
Areas of Research: Histone Modification
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
A70371-05050 µl $249.00 Add to Cart
A70371-100100 µl $399.00 Add to Cart
Antibodies
HAT1 Polyclonal Antibody
HAT1 Polyclonal Antibody

Application: ChIP, IF, IHC, WB
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse, Rat
A-4014-05050 µl $199.00 Add to Cart
A-4014-100100 µl $391.00 Add to Cart
Antibodies
HDAC1 Monoclonal Antibody
HDAC1 Monoclonal Antibody

Citations (2)
Application: WB
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Monoclonal
Conjugate: Unconjugated
Host: Mouse
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
A-4001-05050 µl $199.00 Discontinued
A-4001-100100 µl $391.00 Add to Cart
Antibodies
HDAC1 Polyclonal Antibody
HDAC1 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A68304-02020 µg $59.00 Add to Cart
A68304-05050 µg $256.00 Add to Cart
A68304-100100 µg $359.00 Add to Cart
Antibodies
HDAC1 Polyclonal Antibody, Biotin Conjugated
HDAC1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A59351-05050 µg $256.00 Add to Cart
A59351-100100 µg $359.00 Add to Cart
Antibodies
HDAC1 Polyclonal Antibody, FITC Conjugated
HDAC1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A59352-05050 µg $256.00 Add to Cart
A59352-100100 µg $359.00 Add to Cart
Antibodies
HDAC1 Polyclonal Antibody, HRP Conjugated
HDAC1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A59353-05050 µg $256.00 Add to Cart
A59353-100100 µg $359.00 Add to Cart
Antibodies
HDAC10 Polyclonal Antibody
HDAC10 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A-4010-02020 µg $59.00 Add to Cart
A-4010-05050 µg $242.00 Add to Cart
A-4010-100100 µg $399.00 Add to Cart
Antibodies
HDAC11 Polyclonal Antibody
HDAC11 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Histone Acetylation & Deacetylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
A-4011-05050 µl $242.00 Add to Cart
A-4011-100100 µl $399.00 Add to Cart
Antibodies
Result Pages: [<< Prev]  ... 6  7  8  9  10 ...  [Next >>]  Displaying 181 to 200 (of 1189 products)
Epigentek is an epigenetics company that specializes in epigenetic kits, antibodies, reagents, and services for epigenetic research in DNA methylation, histone modification, and chromatin studies. Terms & Conditions | Privacy Policy | Site Map
Copyright © 2018 Epigentek Group Inc. All rights reserved.