EHMT2 (Euchromatic Histone Lysine Methyltransferase 2) is a histone methyltransferase that specifically mono- and dimethylates Lys-9 of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. H3K9me is a specific tag for epigenetic transcriptional repression by recruiting HP1 proteins to methylated histones. This gene also mediates monomethylation of Lys-56 of histone H3 (H3K56me1) in G1 phase, promoting interaction between histone H3 and PCNA and regulating DNA replication. Also weakly methylates Lys-27 of histone H3 (H3K27me). Also required for DNA methylation, the histone methyltransferase activity is not required for DNA methylation, suggesting that these 2 activities function independently. Most likely targeted to histone H3 by different DNA-binding proteins like E2F6, MGA, MAX and/or DP1. May also methylate histone H1. In addition to the histone methyltransferase activity, also methylates non-histone proteins: mediates dimethylation of Lys-373 of p53/TP53. Also methylates CDYL, WIZ, ACIN1, DNMT1, HDAC1, ERCC6, KLF12 and itself.
EHMT2 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Liquid. PBS with 0.02% sodium azide, 50% glycerol, pH7.3..
Mouse, Rat, Human
Recombinant Protein of Human EHMT2
Shipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.
EHMT2; BAT8; C6orf30; G9A; GAT8; KMT1C; NG36; histone-lysine N-methyltransferase EHMT2
WB, IF; Recommended dilution: WB 1:500 - 1:2000;IF 1:50 - 1:100