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ETHE1 Polyclonal Antibody

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Western blot
All lanes: ETHE1 Polyclonal Antibody at 8ug/ml
Lane 1: Mouse liver tissue
Lane 2: HepG-2 whole cell lysate
Lane 3: Hela whole cell lysate
Secondary
Goat polyclonal to Rabbit IgG at 1/10000 dilution
Predicted band size: 28 kDa
Observed band size: 28 kDa
Immunohistochemistry of paraffin-embedded human colon cancer at dilution of 1:100
Application: ELISA, IHC, WB
Areas of Research: Cell Metabolism
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human, Mouse
Trial Size Available: Yes
100% Guarantee: 6 months
Catalog No.SizePriceQty
A58974-02020 µg $99.00 
A58974-05050 µg $256.00 
A58974-100100 µg $359.00 
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Product Overview

Background
Sulfur dioxygenase that plays an essential role in hydrogen sulfide catabolism in the mitochondrial matrix. Hydrogen sulfide (H(2)S) is first oxidized by SQRDL, giving rise to cysteine persulfide residues. ETHE1 consumes molecular oxygen to catalyze the oxidation of the persulfide, once it has been transferred to a thiophilic acceptor, such as glutathione (R-SSH). Plays an important role in metabolic homeostasis in mitochondria by metabolizing hydrogen sulfide and preventing the accumulation of supraphysiological H(2)S levels that have toxic effects, due to the inhibition of cytochrome c oxidase. First described as a protein that can shuttle between the nucleus and the cytoplasm and suppress p53-induced apoptosis by sequestering the transcription factor RELA/NFKB3 in the cytoplasm and preventing its accumulation in the nucleus (PubMed:12398897).

Description
ETHE1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Formulation
Liquid. 0.03% Proclin 300, 50% Glycerol, 0.01M PBS, PH 7.4.

Specificity
Human, Mouse

Isotype
IgG

Uniprot ID
O95571

Purification
>95%, Protein G purified

Immunogen
Recombinant Human Persulfide dioxygenase ETHE1, mitochondrial protein (8-254AA)

Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.

Alternative Names
Persulfide dioxygenase ETHE1, mitochondrial (EC:1.13.11.182 Publications, ETHE1, HSCO, Ethylmalonic encephalopathy protein 1, Hepatoma subtracted clone one protein, Sulfur dioxygenase ETHE1

Application
ELISA, WB, IHC; Recommended dilution: WB:1:500-2000, IHC:1:20-1:200

User Guide & MSDS

[User Guide]*
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