Wu M et. al. (September 2023). TGFβ1-RCN3-TGFBR1 loop facilitates pulmonary fibrosis by orchestrating fibroblast activation Respir Res. 24(1):222.
This article investigates the mechanisms behind idiopathic pulmonary fibrosis (IPF) highlighting the critical role of Reticulocalbin 3 (RCN3) in promoting fibroblast activation which contributes to the development of lung fibrosis. These findings suggest that targeting RCN3 could be a novel approach for ameliorating pulmonary fibrosis.
Products Used: EpiQuik Total Histone Extraction Kit
Li Q et. al. (September 2023). DNMT3B alleviates liver steatosis induced by chronic low-grade LPS via inhibiting CIDEA expression Cell Mol Gastroenterol Hepatol.
This study investigates the connection between gut dysbiosis, chronic low-grade LPS exposure, and nonalcoholic fatty liver disease (NAFLD). It reveals that LPS disrupts lipid metabolism by suppressing DNMT3B expression, leading to hypomethylation of the CIDEA gene promoter, which increases lipogenesis and causes hepatic steatosis, providing insights into potential NAFLD treatments.
Products Used: MethylFlash Methylated DNA 5-mC Quantification Kit (Colorimetric)
Ganguly A et. al. (September 2023). H.O.S.T.: Hemoglobin microbubble-based Oxidative stress Sensing Technology Sci Rep. 13(1):14942.
The article presents the development of H.O.S.T., a novel biosensor using hemoglobin microbubbles for label-free detection of hydrogen peroxide (H2O2) for applications in oxidative stress and cancer diagnostics. This innovative sensor offers an extended dynamic range, lower detection limit, and enhanced resolution compared to traditional H2O2 biosensors, making it a promising tool for accurate and sensitive detection of H2O2 in cancerous and non-cancerous cell lysates.
Products Used: EpiQuik In-Situ and Ex-Situ Hydrogen Peroxide (H2O2) Assay Kit
Zhang X et. al. (September 2023). Deubiquitinase USP19 modulates apoptotic calcium release and endoplasmic reticulum stress by deubiquitinating BAG6 in triple negative breast cancer Clin Transl Med. 13(9):e1398.
The study explores the role of ubiquitin-specific protease 19 (USP19) in triple-negative breast cancer (TNBC) and its impact on tumor growth and apoptosis. USP19 was found to decrease TNBC cell proliferation and promote apoptosis by interacting with and stabilizing BAG6, which, in turn, affected BCL2 ubiquitination and degradation, leading to increased ER calcium levels and ER stress. These findings suggest that targeting USP19 could be a potential therapeutic strategy for TNBC treatment.
Products Used: piQuik m6A RNA Methylation Quantification Kit (Colorimetric)