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Shi F et. al. (May 2024). Epstein-Barr virus-driven metabolic alterations contribute to the viral lytic reactivation and tumor progression in nasopharyngeal carcinoma J Med Virol. 96(5):e29634.
This study investigates the metabolic changes induced by Epstein-Barr virus (EBV) in nasopharyngeal carcinoma (NPC) and found that EBV-driven alterations contribute to viral reactivation and tumor progression. Researchers discovered that EBV accelerates the secretion of D-2HG, suggesting its potential as a diagnostic biomarker for NPC. These metabolic changes disrupt DNA methylation, reducing 5hmC content, which is associated with poor prognosis in NPC. The researchers also identified α-KG as a novel EBV reactivation inhibitor, suggesting potential therapeutic targets for NPC.
Products Used: EpiQuik Hydroxymethylated DNA Immunoprecipitation (hMeDIP) Kit
Pan JJ et. al. (April 2024). Acetyl-CoA metabolic accumulation promotes hepatocellular carcinoma metastasis via enhancing CXCL1-dependent infiltration of tumor-associated neutrophils Cancer Lett. 592:216903.
This article examines how acetyl-CoA metabolic accumulation affects hepatocellular carcinoma (HCC) metastasis. The researchers found that high levels of acetyl-CoA promote metastasis by enhancing the infiltration of tumor-associated neutrophils (TANs) in the cancer microenvironment. They discovered that acetyl-CoA accumulation induces the upregulation of the chemokine CXCL1, which recruits TANs and promotes HCC metastasis. This study highlights the CXCL1-CXCR2-TANs axis as a potential therapeutic target for HCC with high acetyl-CoA levels.
Products Used: EpiQuik Acetyl-Histone H3 ChIP Kit
Xuan YF et. al. (April 2024). The combination of methionine adenosyltransferase 2A inhibitor and methyltransferase like 3 inhibitor promotes apoptosis of non-small cell lung cancer cells and produces synergistic anti-tumor activity Biochem Biophys Res Commun. 716:150011.
This study investigates the combination of methionine adenosyltransferase 2A (MAT2A) inhibitor and methyltransferase like 3 (METTL3) inhibitor as a potential treatment for non-small cell lung cancer (NSCLC). MAT2A inhibitors are used to treat tumors with methylthioadenosine phosphorylase (MTAP) deficiency, while METTL3 catalyzes mRNA modification. The researchers found that the combination of MAT2A inhibitor AG-270 and METTL3 inhibitor STM2457 induced cell apoptosis in NSCLC, independent of MTAP expression. This combination reduced m6A levels, downregulated PI3K/AKT proteins, and activated apoptosis-related proteins. The study suggests that this combination therapy could be a promising treatment for NSCLC, with synergistic effects observed both in vitro and in vivo.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)
Cheng S et. al. (May 2024). 20(S)-ginsenoside Rh2 ameliorates ATRA resistance in APL by modulating lactylation-driven METTL3 J Ginseng Res. 48(3):298-309.
This study explores how 20(S)-ginsenoside Rh2 (GRh2) could help overcome resistance to all-trans retinoic acid (ATRA) in acute promyelocytic leukemia (APL). It focuses on lactylation-driven METTL3, a protein found at high levels in ATRA-resistant APL cells. The researchers discovered that METTL3, influenced by histone lactylation, plays a role in ATRA resistance. They also found that GRh2 can reduce lactylation levels and inhibit METTL3, potentially restoring sensitivity to ATRA in APL.
Products Used: Epigenase m6A Methylase Activity/Inhibition Assay Kit (Colorimetric)
Xu H et. al. (May 2024). Paeoniflorin exerts anti-PTSD effects in adult rats by modulating hippocampus and amygdala histone acetylation modifications in response to early life stress Chem Biol Interact. :111035.
This article investigates the impact of early life stress (ELS) on susceptibility to post-traumatic stress disorder (PTSD) in adulthood, focusing on histone acetylation modifications in the hippocampus and amygdala. The researchers used paeoniflorin (PF) to assess its potential anti-PTSD effects in adult rats exposed to ELS. They found that ELS led to PTSD-like behaviors in adulthood and altered the balance of histone acetylation enzymes in the hippocampus and amygdala, suggesting ELS as a risk factor for adult PTSD development. Furthermore, PF treatment improved ELS-induced PTSD-like behaviors and reduced susceptibility to PTSD by modulating histone acetylation in these brain regions.
Products Used: EpiQuik Nuclear Extraction Kit
