Epigenetic Research Papers 3/3/25 - 3/7/25

Chang K et. al. (February 2025). FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism Chang K et. al. (February 2025).
This study investigates the role of FTO-mediated m6A modification in podocyte injury and diabetic nephropathy (DN) progression. The findings reveal that FTO stabilizes ACC1 mRNA in an m6A-dependent manner, promoting fatty acid metabolism and contributing to podocyte lipotoxicity. Inhibiting FTO activity mitigates lipid accumulation and podocyte injury, highlighting its potential as a therapeutic target for DN.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric), EpiQuik CUT&RUN m6A RNA Enrichment (MeRIP) Kit

Li Z et. al. (February 2025). LATERAL FLORET 2 encoding a sucrose non-fermenting 2 chromatin remodeling factor regulates axillary meristem of spikelet development in rice (Oryza sativa) New Phytol.
This study explores the role of the LATERAL FLORET 2 (LF2) gene in regulating axillary meristem initiation and spikelet development in rice. LF2 encodes a chromatin remodeling factor that interacts with nuclear factors and influences auxin signaling and gene expression, including the regulation of the G1 gene for sterile lemma identity. The findings provide new insights into the genetic and epigenetic mechanisms controlling rice inflorescence architecture.
Products Used: EpiQuik Plant ChIP Kit

Du L et. al. (February 2025). GABP Promotes Mesangial Cell Proliferation and Renal Fibrosis Through GLI1 in Diabetic Nephropathy Adv Sci (Weinh). :e2407462.
This study examines the role of GA-binding protein (GABP) in promoting mesangial cell proliferation and renal fibrosis in diabetic nephropathy. GABP regulates these processes by activating GLI1, which drives cell cycle progression, and its deficiency mitigates hyperglycemia-induced proliferation in a diabetic mouse model. These findings suggest that targeting GABP may offer a potential therapeutic strategy for diabetic nephropathy.
Products Used: ChromaFlash One-Step Magnetic ChIP Kit

Hua Z et. al. (February 2025). Silencing YTHDF2 Induces Apoptosis of Neuroblastoma Cells In a Cell Line-Dependent Manner via Regulating the Expression of DLK1 Mol Neurobiol.
This study investigates the role of YTHDF2 in regulating neuroblastoma (NB) cell proliferation and apoptosis through its interaction with DLK1 mRNA. Silencing YTHDF2 induces apoptosis in a cell line-dependent manner by modulating DLK1 expression, with retinoic acid treatment reducing both YTHDF2 and DLK1 levels. These findings suggest that YTHDF2 and DLK1 may serve as potential therapeutic targets for neuroblastoma.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)

Irisarri A et. al. (February 2025). FTO inhibition mitigates high-fat diet-induced metabolic disturbances and cognitive decline in SAMP8 mice Mol Med. 31(1):73.
This study examines the effects of FTO inhibition on metabolic dysfunction and cognitive decline in SAMP8 mice fed a high-fat diet. Treatment with the FTO inhibitor FB23 improved glucose tolerance, modulated lipid metabolism and neuroinflammatory markers, and enhanced synaptic plasticity. Behavioral tests further demonstrated that FTO inhibition rescued cognitive impairments, suggesting a potential therapeutic strategy for obesity-induced cognitive decline and neurodegeneration.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)

Kapadia B et. al. (February 2025). m6A eraser ALKBH5/treRNA1/DDX46 axis regulates BCR expression Kapadia B et. al. (February 2025).
This study investigates the role of the ALKBH5/treRNA1/DDX46 axis in regulating B-cell receptor (BCR) expression through m6A demethylation. The findings reveal that ALKBH5, along with treRNA1 and DDX46, removes m6A marks on key transcripts, enhancing their stability and translation. Disruption of this pathway impairs BCR-related gene expression, highlighting a novel epitranscriptomic mechanism with potential therapeutic implications for immune regulation and cancer.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)

Zhang F et. al. (February 2025). FTO triggers NLRP3/GSDMD-dependent pyroptosis to enhance cisplatin-sensitivity in ovarian cancer Cell Signal. :111698.
This study explores the role of FTO in enhancing cisplatin sensitivity in ovarian cancer by triggering NLRP3/GSDMD-dependent pyroptosis. The findings reveal that FTO is downregulated in cisplatin-resistant cells, and its overexpression reduces m6A modification on NLRP3 mRNA, promoting pyroptosis and increasing drug sensitivity. These results suggest that targeting FTO may offer a potential strategy to overcome chemoresistance in ovarian cancer.
Products Used: EpiQuik m6A RNA Methylation Quantification Kit (Colorimetric)

Chen H et. al. (February 2025). JMJD6 K375 acetylation restrains lung cancer progression by enhancing METTL14/m6A/SLC3A2 axis mediated cell ferroptosis J Transl Med. 23(1):233.
This study examines the role of JMJD6 K375 acetylation in restraining lung cancer progression by modulating ferroptosis through the METTL14/m6A/SLC3A2 axis. The findings reveal that JMJD6 acetylation weakens its demethylase activity, enhancing METTL14 expression and promoting m6A modification of SLC3A2, thereby increasing ferroptosis sensitivity in lung cancer cells. These results suggest that targeting JMJD6 acetylation could serve as a potential therapeutic strategy for non-small cell lung cancer.
Products Used: EpiQuik CUT&RUN m6A RNA Enrichment (MeRIP) Kit

Singh S et. al. (March 2025). Environmental pollutant SO₂ exposure affects trophoblast function involving an ER stress pathway J Physiol. 603(5):1263-1279.
This study investigates the impact of sulfur dioxide (SO₂) exposure on trophoblast function, highlighting its potential role in pregnancy complications. The findings reveal that SO₂ derivatives impair trophoblast invasion, migration, and fusion, likely through dysregulated endoplasmic reticulum (ER) stress and altered histone modifications. These results suggest that SO₂ exposure disrupts placental function, which may contribute to adverse pregnancy outcomes.
Products Used: EpiQuik Total Histone Extraction Kit