C3-C3a Polyclonal Antibody

Background
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form the mature protein, which is then further processed to generate numerous peptide products. The C3a peptide, also known as the C3a anaphylatoxin, modulates inflammation and possesses antimicrobial activity. Mutations in this gene are associated with atypical hemolytic uremic syndrome and age-related macular degeneration in human patients.

Description
C3-C3a Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Formulation
Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Specificity
Human, Mouse, Rat

Isotype
IgG

Uniprot ID
P01024

Purification
Affinity Purified

Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1364-1663 of human C3 / C3a (NP_000055.2)

Storage
Shipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles

Alternative Names
C3; AHUS5; ARMD9; ASP; C3a; C3b; CPAMD1; HEL-S-62p; complement C3

Application
WB, IF