N-terminal alpha-synuclein Monoclonal Antibody [MJFF-B-3A4]NewKO Validated

Background
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Alpha-synuclein is a neuronal protein that plays many roles in synaptic activity such as membrane trafficking of synaptic vesicles and neurotransmitter release. Multiplications in SNCA have been implicated in genetic forms of Parkinson disease and pathological post-translational modifications of alpha-synuclein are a hallmark of Parkinson's disease. These modifications include phosphorylation, nitration, acetylation, truncation, and aggregation.

Description
N-terminal alpha-synuclein Monoclonal Antibody [MJFF-B-3A4]. Unconjugated. Raised in: Rabbit.

Formulation
Buffer: PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH7.3.

Specificity
Human, Mouse, Rat

Isotype
IgG

Uniprot ID
P37840

Purification
Affinity Purified

Immunogen
Synthetic peptide. Please contact EpigenTek for more information.

Storage
Store at -20°C. Avoid freeze / thaw cycles.

Alternative Names
NACP; PARK1; a-Synuclein; SNCA

Application
WB, IF/ICC, ELISA; Recommended dilution: WB, 1:5000 - 1:30000; IF/ICC, 1:200 - 1:500; ELISA, Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.