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SMYD2 Polyclonal Antibody

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Western blot analysis of extracts of various cell lines, using SMYD2 Polyclonal Antibody.
Application: WB
Areas of Research: Other Histone Modification
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse
100% Guarantee: 6 months
Catalog No.SizePriceQty
A-3730-05050 µl $266.00  Discontinued
A-3730-100100 µl $465.00 
Availability: Usually Ships in 3-4 Days 
Product Overview

Background
SMYD2 (SET and MYND Domain Containing 2) is a member of the SMYD family of protein methyltransferases. All family members (SMYD1, SMYD2, SMYD3, SMYD4, and SMYD5) contain a conserved catalytic SET domain, first identified in Drosophila Su[var]3-9, Enhancer of zeste, and Trithorax proteins. Split by the MYN domain/zinc finger motif, this domain is believed to facilitate protein-protein interactions. SMYD2 localizes to cytoplasm and the nucleus and is also highly expressed in mouse heart, brain, liver, kidney, thymus, and ovary, as well as in the developing embryo of the mouse. SMYD2 is able to repress transcription by interacting with the Sin3A repressor complex and methylating lys36 of histone H3. SMYD2 also interacts with HSP90alpha and methylates lys4 of histone H3. Additionally, SMYD2 can methylate p53 at lys370 to repress p53-mediated transcriptional activation and apoptosis.

Description
SMYD2 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Specificity
Human, Mouse

Isotype
IgG

Uniprot ID
Q9NRG4

Purification
Affinity Purified

Immunogen
Synthetic Peptide of Human SMYD2

Storage
Shipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.

Alternative Names
KMT3C, HSKM-B, ZMYND14

Application
WB

User Guide & MSDS

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