SIRT4 is a member of the sirtuin (silent mating type information regulation 2 homolog) family of proteins which are characterized by a sirtuin core domain and are grouped into 4 class types. Sirtuins share NAD dependency for their enzymatic activity, but some show NAD-dependent deacetylase activity, while others exhibit ADP ribosyltransferase activity or both. Sirtuins may act to influence a wide range of cellular processes such as aging, transcription, apoptosis, inflammation and stress resistance. Seven members make up the family of sirtuins in mammals (SirT1-T7). SIRT4 is a Class II sirtuin.
Mouse monoclonal antibody raised against a partial recombinant SIRT4, clone 1C8.
Protein A purified
SIRT4 (NP_036372, 215 a.a. ~ 315 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
In 1x PBS, pH 7.2
Aliquot and store at -20ºC or lower. Avoid repeated freezing and thawing. Multiple freeze/thaw cycles may result in decreased performance.
For maximum recovery of the products, centrifuge the vial prior to opening the cap.
Sirtuin4, MGC130046 antibody, MGC130047 antibody, MGC57437 antibody, NAD dependent deacetylase sirtuin 4 antibody, NAD-dependent ADP-ribosyltransferase sirtuin-4 antibody, Regulatory protein SIR2 homolog 4 antibody, Silent mating type information regulation 2 homolog antibody, Sir 2 like 4 antibody, SIR2L 4 antibody, sirtuin 4 antibody, sirtuin silent mating type information regulation 2 homolog 4 (S. cerevisiae) antibody
Applications & Suggested Dilutions*
Western Blot: 0.5-1 µg/ml
ELISA: 0.25-1 µg/ml