C-Reactive Protein (CRP) Monoclonal Antibody

Background
The protein encoded by this gene belongs to the pentraxin family, which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, as well as complement regulation via recruitment of complement regulators. The encoded protein has a calcium-dependent ligand-binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms, either as a pentamer in circulation or as a non-soluble monomer in tissues. It is involved in several host defense-related functions based on its ability to recognize foreign pathogens and damaged host cells, and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli. Elevated expression of the encoded protein is associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

Description
C-Reactive Protein (CRP) Monoclonal Antibody. Unconjugated. Raised in: Rabbit.

Formulation
Buffer: PBS containing 50% glycerol and 0.05% BSA, preserved with proclin300 or sodium azide, pH 7.3.

Specificity
Human, Mouse

Isotype
IgG

Uniprot ID
P02741

Purification
Affinity Purified

Immunogen
Synthetic peptide. Please contact EpigenTek for more information.

Storage
Store at -20°C. Avoid freeze / thaw cycles.

Alternative Names
PTX1; C-Reactive Protein (CRP)

Application
WB, IHC-P, ELISA; Recommended dilution: WB, 1:1000 - 1:2000; IHC-P, 1:100 - 1:400; ELISA, Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.