Histone methylation is a process by which methyl groups are added to the amino-terminal tails of histone proteins. This modification can affect the way that the DNA wrapped around histones is packaged, and can have a major impact on how genes are expressed. Depending on the specific modification and the context in which it occurs, histone methylation can have either activating or repressive effects.
Histone methylation is not a static modification, but rather a dynamic process that can be influenced by different factors and can be reversed. Histone methyltransferases (HMTs) are enzymes that transfer a methyl group from a methyl donor molecule, such as S-adenosyl methionine (SAM), to a specific residue on a histone protein, while histone demethylases (HDMs) catalyze the reverse reaction. Both HMTs and HATs often act as part of larger protein complexes, which can also include other chromatin-modifying enzymes, and non-histone proteins, like transcription factors and chromatin remodelers. These complexes can work together to create specific chromatin environments that promote or repress gene expression.
What makes buying antibodies from EpiGentek different?
At EpiGentek, we supply a collection of over 20,000 individual high-quality antibodies for our customers to ensure that our research customers find exactly what they need for their studies. In addition, we offer a variety of other benefits to help our customers in terms of affordability, convenience, and reliability. See why working with EpiGentek for your antibodies is the right choice:
No Shipping & Handling Costs: we’ve waived all shipping and handling fees on our antibodies and antibody panel packs when selecting 2-day shipping (trial sizes not applicable).
100% Application Guarantee: your purchased antibodies are covered for 6-months past the date of purchase.
Multiple Conjugates: we carry biotin, FITC and HRP conjugates for nearly all targets.
Trial Sizes Available: 10 & 20 µl options available for thousands of antibodies in our catalog.