BackgroundThis gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. This FAD-binding protein forms homodimers and reduces quinones to hydroquinones. This protein's enzymatic activity prevents the one electron reduction of quinones that results in the production of radical species. Mutations in this gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of this protein has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
DescriptionNQO1 Monoclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.09% Sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
SpecificityHuman, Mouse, Rat
IsotypeIgG
Uniprot IDP15559
PurificationAffinity Purified
ImmunogenRecombinant protein (or fragment). Please contact EpigenTek for more information.
StorageStore at -20°C. Avoid freeze / thaw cycles.
Alternative NamesDTD; QR1; DHQU; DIA4; NMOR1; NMORI; [KD Validated] NQO1
ApplicationWB, IF-P, IHC-P, ELISA; Recommended dilution: WB, 1:20000 - 1:200000; IF-P, 1:100 - 1:500; IHC-P, 1:500 - 1:2000; ELISA, Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
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