Modulators & Inhibitors

DNA methylation modulators and inhibitors are useful for studying the common epigenetic mechanism known as DNA methylation, which entails the addition of a methyl group onto DNA. Using enzyme inhibition assays, various DNA methylation modulators and inhibitors have been shown to display antitumor and antioxidant properties, inhibit telomerase and DNA methyltransferase (DNMT) activity, and block activation of various receptors.

Modulators and inhibitors are used in enzyme inhibition assays to study histone acetylation, or the addition of an acetyl group on a histone, which then affects the regulation of transcription through chromatin remodeling. Certain epigenetic modulators and inhibitors specific to histone acetylation studies have been shown to inhibit histone acetyltransferases (HATs) such as p300/CBP associated factor histone acetyltransferase, inhibit the transcription factor NF kappa B, promote apoptosis thr...

Modulators and inhibitors are used in enzyme inhibition assays to study histone deacetylation, or the removal of an acetyl group on a histone, which impacts the regulation of DNA expression. Histone deacetylation modulators and inhibitors inhibit histone deacetylases (HDACs) also called lysine deacetylases (KDACs). They are crucial to advancing epigenetic research in cell cycle regulation, cell proliferation, and development of cancer.

Histone demethylation is defined as the removal of methyl groups from histone proteins by histone demethylases (KDMs), which affects the inactivation of chromatin and therefore gene expression. Histone demethylation modulators and inhibitors inhibit histone demethylases (HDMs) and offer insight into diseases such as breast cancer, prostate cancer, and lung cancer that are related to histone demethylation.

Histone methylation is described as the transfer of methyl groups to histone proteins (commonly H3 and H4) by histone methyltransferases (HMTs), which affects the activation of chromatin and therefore gene expression. Histone methylation modulators and inhibitors inhibit histone methyltransferases and allow researchers to study diseases, especially cancer, that are related to histone methylation.

Histone phosphorylation has been implicated in numerous processes such as transcription, DNA repair, cell cycle progression and apoptosis, and chromosome condensation. These histone phosphorylation modulators and inhibitors act to inhibit proteases and phosphatases for research investigating diseases connected to phosphorylation such as Alzheimer’s and Huntington’s disease.