Epigentek Home
 
EpiGentek Guarantee
Refine Your Results
MethylFlash ELISA Easy
Modulators & Inhibitors

Modulators & Inhibitors

DNA Methylation
DNA methylation modulators and inhibitors are useful for studying the common epigenetic mechanism known as DNA methylation, which entails the addition of a methyl group onto DNA. Using enzyme inhibition assays, various DNA methylation modulators and inhibitors have been shown to display antitumor and antioxidant properties, inhibit telomerase and DNA methyltransferase (DNMT) activity, and block activation of various receptors.

Histone Acetylation
Modulators and inhibitors are used in enzyme inhibition assays to study histone acetylation, or the addition of an acetyl group on a histone, which then affects the regulation of transcription through chromatin remodeling. Certain epigenetic modulators and inhibitors specific to histone acetylation studies have been shown to inhibit histone acetyltransferases (HATs) such as p300/CBP associated factor histone acetyltransferase, inhibit the transcription factor NF kappa B, promote apoptosis thr...

Histone Deacetylation
Modulators and inhibitors are used in enzyme inhibition assays to study histone deacetylation, or the removal of an acetyl group on a histone, which impacts the regulation of DNA expression. Histone deacetylation modulators and inhibitors inhibit histone deacetylases (HDACs) also called lysine deacetylases (KDACs). They are crucial to advancing epigenetic research in cell cycle regulation, cell proliferation, and development of cancer.

Histone Demethylation
Histone demethylation is defined as the removal of methyl groups from histone proteins by histone demethylases (KDMs), which affects the inactivation of chromatin and therefore gene expression. Histone demethylation modulators and inhibitors inhibit histone demethylases (HDMs) and offer insight into diseases such as breast cancer, prostate cancer, and lung cancer that are related to histone demethylation.

Histone Methylation
Histone methylation is described as the transfer of methyl groups to histone proteins (commonly H3 and H4) by histone methyltransferases (HMTs), which affects the activation of chromatin and therefore gene expression. Histone methylation modulators and inhibitors inhibit histone methyltransferases and allow researchers to study diseases, especially cancer, that are related to histone methylation.

Histone Phosphorylation
Histone phosphorylation has been implicated in numerous processes such as transcription, DNA repair, cell cycle progression and apoptosis, and chromosome condensation. These histone phosphorylation modulators and inhibitors act to inhibit proteases and phosphatases for research investigating diseases connected to phosphorylation such as Alzheimer’s and Huntington’s disease.

Result Pages: [<< Prev]   1  2  Displaying 21 to 22 (of 22 products)
VX-680 (MK-0457, Tozasertib)
VX-680 (MK-0457, Tozasertib)

Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Phosphorylation
Solubility: DMSO
M73000-125 mg $98.00 Discontinued
Modulators & Inhibitors
ZM-447439
ZM-447439

Application: Enzyme Inhibition
Molecular Weight: >500
Research Area: Histone Phosphorylation
Solubility: DMSO
M75001-11 mg $168.00 Discontinued
Modulators & Inhibitors
Result Pages: [<< Prev]   1  2  Displaying 21 to 22 (of 22 products)
Epigentek is an epigenetics company that specializes in epigenetic kits, antibodies, reagents, and services for epigenetic research in DNA methylation, histone modification, and chromatin studies. Terms & Conditions | Privacy Policy | Site Map
Copyright © 2019 Epigentek Group Inc. All rights reserved.

Intro to Epigenetics