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ZM-447439

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Application: Enzyme Inhibition
Molecular Weight: >500
Research Area: Histone Phosphorylation
Solubility: DMSO
100% Guarantee: 6 months
Catalog No.SizePriceQty
M75001-11 mg $163.00 
Availability: Usually Ships In 1-2 Days 
Product Overview

Alternative Names
N-[4-[[6-Methoxy-7-[3-(4-morpholinyl)propoxy]-4-quinazolinyl]amino]phenyl]benzamide

Description
ZM-447439 is a selective inhibitor of aurora kinases ARK-1 (A) (IC50=1000nM, Ki=100nM), ARK-2 (B) (IC50= 50nM, Ki= 0.36nM) and ARK-3 (C), that can induce growth arrest, inhibit histone H3 phosphorylation and effectively activate apoptosis. The compound specifically interacts at the ATP-binding site and at the adjacent cleft, found only in aurora kinases. In the presence of Z-M447439, chromosome alignment, segregation, and cytokinesis during mitosis are unsuccessful. Studies show that ZM-447439 can override the spindle assembly checkpoint and accelerate meiosis I in mouse oocytes.

CAS Number
331771-20-1

Chemical Formula
C29H31N5O5

Molecular Weight
513.6

Size
1 mg

Purity
>98%

Solubility
Soluble in DMSO (25 mg/mL)

Storage Temp
-20°C

User Guide & MSDS

[User Guide]*
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