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VX-680 (MK-0457, Tozasertib)

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Application: EnzymeInhibition
Molecular Weight: 100-500
Research Area: Histone Phosphorylation
Solubility: DMSO
100% Guarantee: 6 months
Catalog No.SizePriceQty
M73000-125 mg $98.00  Discontinued
Availability: Discontinued 
Product Overview

Alternative Names
Tozasertib VX 680

Description
MK 0457 is a potent pan-Aurora kinase inhibitor but favors Aurora A (Ki = 0.6 nM) over Aurora B (Ki = 18 nM) or Aurora C (Ki = 4.6 nM). It shows selectivity against a panel of more than 190 different protein kinases. MK 0457 effectively inhibits proliferation of several different cell lines of clear cell renal carcinoma (IC50s < 10 µM) and blocks the growth of tumors in a rodent model of cancer (80 mg/kg), inhibiting histone H3 phosphorylation and increasing apoptosis. By depleting Aurora activity, MK 0457 disrupts bipolar spindle formation during mitosis, arresting cell cycle progression at the G2/M phase.

CAS Number
639089-54-6

Chemical Formula
C23H28N8OS

Molecular Weight
464.6

Size
25 mg

Purity
≥98%

Solubility

DMSO

Storage Temp
-20°C

User Guide & MSDS

[User Guide]*
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