BackgroundCore component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.
DescriptionHistone Histone H2A.2 Recombinant Monoclonal Antibody [1H12]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP04908
PurificationAffinity Chromatography
ImmunogenA synthesized peptide
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesHistone H2A type 1-B/E, Histone H2A.2, Histone H2A/a, Histone H2A/m, HIST1H2AB, H2AFM, HIST1H2AE, H2AFA, Histone H2A type 1-B/E
ApplicationELISA, WB, IF; Recommended dilution: WB:1:500-1:5000, IF:1:30-1:200