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Mo A et. al. (October 2024). WTAP-mediated m6A modification regulates NLRP3/Caspase-1/GSDMD to inhibit pyroptosis and exacerbate colorectal cancer Biomark Med. :1-11.
This study shows that WTAP, which is highly expressed in colorectal cancer (CRC), promotes cancer cell proliferation, migration, and invasion while inhibiting apoptosis. WTAP mediates m6A modifications on NLRP3, repressing the NLRP3/Caspase-1/GSDMD pathway involved in pyroptosis, a type of inflammatory cell death. By suppressing this pathway, WTAP contributes to CRC progression, highlighting it as a potential therapeutic target for managing CRC.
Products Used: EpiQuik CUT&RUN m6A RNA Enrichment (MeRIP) Kit
Kaushik A et. al. (October 2024). Hypertension and global DNA methylation: a population-based study in rural, Punjab, India Sci Rep. 14(1):25826.
This study in rural Punjab, India, found that hypertension is associated with lower global DNA methylation levels, indicating an epigenetic link to hypertension risk. Folate sufficiency may improve methylation in hypertensive individuals with controlled blood pressure, suggesting a potential dietary aid in managing hypertension.
Products Used: MethylFlash Global DNA Methylation (5-mC) ELISA Easy Kit (Colorimetric)
Bozó R et. al. (October 2024). The Expression of Cytokines and Chemokines Potentially Distinguishes Mild and Severe Psoriatic Non-Lesional and Resolved Skin from Healthy Skin and Indicates Different Stages of Inflammation Int J Mol Sci. 25(20)
This study found that cytokine and chemokine expression in non-lesional psoriatic skin differs by severity, potentially indicating stages of inflammation and tissue organization. In severe cases, expression changes involve MECP2 and extracellular matrix-related pathways. Resolved skin shows distinct cytokine patterns compared to both mild and severe cases, suggesting unique inflammatory and epigenetic regulation in psoriatic skin based on disease state.
Products Used: 5-Methylcytosine (5-mC) Monoclonal Antibody [33D3]
