This product was discontinued; sorry for the inconvenience. We recommend the following: Cat.# A52130.
BackgroundThis gene encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form.
DescriptionCOL17A1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
SpecificityHuman, Rat
IsotypeIgG
Uniprot IDQ9UMD9
PurificationAffinity Purification
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 1300-1400 of human COL17A1 (NP_000485.3).
StorageShipped at 4°C. Upon receipt, store at -20°C. Avoid freeze / thaw cycles
Alternative NamesCOL17A1; BA16H23.2; BP180; BPA-2; BPAG2; ERED; LAD-1; collagen alpha-1(XVII) chain
ApplicationWB; Recommended dilution: WB: 1:500-1:2000