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Chromatin & Transcription Antibodies

Antibodies that target proteins associated with chromatin and transcription such as histone deacetylases (HDACs), histone acetyltransferases (HATs), histone methyltransferases (HMTs), and heterochromatin protein 1 (HP1) are important to understanding the epigenetic regulation of chromatin structure and its function. Chromatin is involved in crucial functions of the cell including division, replication, and gene expression.

Chromatin remodeling antibodies may assist researchers in investigating several families of chromatin remodelers in eukaryotes, including the SWI/SNF, ISWI, CHD, and INO80 family of chromatin remodelers. These chromatin remodeling families share a conserved ATPase domain for ATP-hydrolysis and DNA binding. Other families have epigenetic reader domains which allow them to bind methylated histones or acetylated histones, for example. Many researchers study chromatin remodeling and protein-DNA interactions with ChIP.

DNA replication & transcription antibodies are useful especially for studying the regulation of gene expression. Transcription factors are proteins that bind to DNA that can alter the expression of certain genes. Transcription factors might also catalyze histone acetylation or histone deacetylation. Certain stimuli during development can lead transcription factors to downregulate or upregulate gene expression at particular times, ensuring proper growth. They are also highly implicated in cancer research as they can act as oncogenes or tumor suppressors.

Cell growth antibodies can be used by epigenetic researchers to investigate transcription factors which activate the expression of certain gene sets related to cell cycle progression and cellular growth. For example, the E2F family of transcription factors controls the progression of the cell cycle by inducing the transcription of genes needed to enter into the cell cycle’s S-phase.

Development & differentiation antibodies offer insight into the process by which an organism develops from a single cell and forms into multiple types of cells, creating various organs and tissues. For example, the HOX genes are an important group of genes that control cellular differentiation during development. They are expressed later in the process of development by tissue stem cells in order to differentiate into their lineages. In addition, embryonic stem cells express transcription factors crucial for pluripotency, such as NANOG and OCT3/4 (POU5F1). Somatic cells can be reprogrammed to become induced pluripotent cells (iPS) by introducing transcription factors SOX2, KLF4, NANOG and OCT3/4.

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At EpiGentek, we supply a collection of over 20,000 individual high-quality antibodies for our customers to ensure that our research customers find exactly what they need for their studies. In addition, we offer a variety of other benefits to help our customers in terms of affordability, convenience, and reliability. See why working with EpiGentek for your antibodies is the right choice:

No Shipping & Handling Costs: we’ve waived all shipping and handling fees on our antibodies and antibody panel packs when selecting 2-day shipping (trial sizes not applicable).
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Multiple Conjugates: we carry biotin, FITC and HRP conjugates for nearly all targets.
Trial Sizes Available: 10 & 20 µl options available for thousands of antibodies in our catalog.

Chromatin Remodeling Antibodies

Chromatin remodeling refers to structural changes in chromatin that transform chromatin from a tight condensed conformation to a looser more permissive conformation. This allows access of transcription factors and other gene regulatory proteins to the DNA, leading to gene activation. Such changes are predominantly mediated by histone modifying enzymes, which catalyze the addition or removal of post-translational modifications to histones, and by several multiprotein chromatin remodeling complexes, which can alter nucleosome positioning. Besides its key role in regulating transcription and gene expression, chromatin remodeling is crucial for DNA replication and repair, as well as other cellular processes.

DNA Replication & Transcription Antibodies

DNA replication is the process by which DNA is duplicated or copied prior to cell division, and which allows the daughter cell to retain a set of its own genetic material. During this process, the two DNA strands are unwound by helicases forming replication forks, and DNA is copied by DNA polymerases to form daughter DNA strands. In eukaryotic cells, the nucleosomes at replication forks must be disassembled and then assembled back. DNA replication progresses by duplication of the DNA at several replication origins. DNA replication follows a semiconservative model, where each daughter cell retains an original parental DNA strand and a newly synthesized daughter strand.

Cell Growth Antibodies

Cell growth can refer to an increase in cell number, by proliferation and cell division, or to an increase in the cells volume, without cell division. Growth of a cell population or cell doubling is dependent on cell division, and involves the completion of successive cell cycles. Cell growth in terms of volume, is when the cytoplasm and organelles of a cell increase in volume due to increased transcription and protein synthesis. This occurs during G1 and G2 phases of the cell cycle, in preparation of the cell prior to DNA duplication during S-phase, or prior to cell division into two daughter cells during the mitotic phase.

Development & Differentiation Antibodies

Development and differentiation includes processes by which a multicellular organism starts out from a single cell, a zygote, and gives rise to multiple cell types, forming different tissues and organs. Development comprises cell division, tissue and organ formation, body axis determination and cellular differentiation.

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Displaying 1741 to 1760 (of 2673 products)

SMAD3 Polyclonal Antibody

Application:	IF, WB
Areas of Research:	DNA Replication & Transcription
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Affinity Purified
Reactivity:	Human, Mouse, Rat

A71445-100

100 µl

$408.00

Antibodies

SMAD3 Polyclonal Antibody

Application:	ELISA, WB
Areas of Research:	Transcription Factors
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A54649-020	20 µl	$102.00	Discontinued
A54649-050	50 µl	$264.00	Discontinued
A54649-100	100 µl	$399.00

Antibodies

SMAD3 Polyclonal Antibody

Application:	WB
Areas of Research:	DNA Replication & Transcription
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Affinity Purified
Reactivity:	Human

A71443-100

100 µl

$408.00

Antibodies

SMAD3 Polyclonal Antibody

Application:	IF, WB
Areas of Research:	DNA Replication & Transcription
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Affinity Purified
Reactivity:	Human, Mouse, Rat

A71444-100

100 µl

$408.00

Antibodies

SMAD3 Polyclonal Antibody, Biotin Conjugated

Application:	ELISA
Areas of Research:	Transcription Factors
Clonality:	Polyclonal
Conjugate:	Biotin
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A54652-050	50 µl	$286.00
A54652-100	100 µl	$399.00

Antibodies

SMAD3 Polyclonal Antibody, FITC Conjugated

Application:	ELISA
Areas of Research:	Transcription Factors
Clonality:	Polyclonal
Conjugate:	FITC
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A54651-050	50 µl	$286.00
A54651-100	100 µl	$399.00

Antibodies

SMAD3 Polyclonal Antibody, HRP Conjugated

Application:	ELISA
Areas of Research:	Transcription Factors
Clonality:	Polyclonal
Conjugate:	HRP
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A54650-050	50 µl	$286.00
A54650-100	100 µl	$399.00

Antibodies

SMAD4 Polyclonal Antibody

Application:	IF, WB
Areas of Research:	DNA Replication & Transcription, Signal Transduction, Transcription Factors, Transcription Factors
Clonality:	Polyclonal Antibodies
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Knockout Validated:	Yes
Purification:	Affinity Purified
Reactivity:	Human, Mouse

A73379-100

100 µl

$557.00

Antibodies

SMAD4 Polyclonal Antibody

Application:	IF, IHC, WB
Areas of Research:	DNA Replication & Transcription
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Affinity Purified
Reactivity:	Human, Mouse, Rat

A72665-100

100 µl

$408.00

Antibodies

SMAD4 Polyclonal Antibody

Application:	ELISA, IHC, IP, WB
Areas of Research:	Transcription Factors
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A64766-020	20 µl	$102.00	Discontinued
A64766-050	50 µl	$264.00	Discontinued
A64766-100	100 µl	$399.00

Antibodies

SMAD4 Polyclonal Antibody, Biotin Conjugated

Application:	ELISA
Areas of Research:	Transcription Factors
Clonality:	Polyclonal
Conjugate:	Biotin
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A64769-050	50 µl	$286.00
A64769-100	100 µl	$399.00

Antibodies

SMAD4 Polyclonal Antibody, FITC Conjugated

Application:	ELISA
Areas of Research:	Transcription Factors
Clonality:	Polyclonal
Conjugate:	FITC
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A64768-050	50 µl	$286.00
A64768-100	100 µl	$399.00

Antibodies

SMAD4 Polyclonal Antibody, HRP Conjugated

Application:	ELISA
Areas of Research:	Transcription Factors
Clonality:	Polyclonal
Conjugate:	HRP
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A64767-050	50 µl	$286.00
A64767-100	100 µl	$399.00

Antibodies

SMAD4 Recombinant Monoclonal Antibody [22H12]

Application:	ELISA, WB
Areas of Research:	DNA Replication & Transcription
Clonality:	Monoclonal
Conjugate:	Unconjugated
Host:	HEK293F Cell
Isotype:	Rabbit IgG
Purification:	Affinity Chromatography
Reactivity:	Human
Recombinant:	Yes

A73817-050	50µl	$299.00
A73817-100	100µl	$399.00

Antibodies

SMARCA2 Polyclonal Antibody

Application:	ChIP, ELISA, IHC
Areas of Research:	Chromatin Remodeling
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human
Trial Size Available:	Yes

A68318-020	20 µl	$111.00
A68318-050	50 µl	$286.00
A68318-100	100 µl	$399.00

Antibodies

SMARCA2 Polyclonal Antibody, Biotin Conjugated

Application:	ELISA
Areas of Research:	Chromatin Remodeling
Clonality:	Polyclonal
Conjugate:	Biotin
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A56454-050	50 µl	$286.00
A56454-100	100 µl	$399.00

Antibodies

SMARCA2 Polyclonal Antibody, FITC Conjugated

Application:	ELISA
Areas of Research:	Chromatin Remodeling
Clonality:	Polyclonal
Conjugate:	FITC
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A56453-050	50 µl	$286.00
A56453-100	100 µl	$399.00

Antibodies

SMARCA2 Polyclonal Antibody, HRP Conjugated

Application:	ELISA
Areas of Research:	Chromatin Remodeling
Clonality:	Polyclonal
Conjugate:	HRP
Host:	Rabbit
Isotype:	IgG
Purification:	Protein G Purified
Reactivity:	Human

A56452-050	50 µl	$286.00
A56452-100	100 µl	$399.00

Antibodies

SMARCA4 Polyclonal Antibody

Application:	IF, IHC, IP, WB
Areas of Research:	Chromatin Remodeling
Clonality:	Polyclonal
Conjugate:	Unconjugated
Host:	Rabbit
Isotype:	IgG
Knockout Validated:	Yes
Purification:	Affinity Purified
Reactivity:	Human, Mouse, Rat

A-2746-050	50 µl	$203.00	Discontinued
A-2746-100	100 µl	$321.00	Discontinued

Antibodies

SMARCA4 Recombinant Monoclonal Antibody [22F3]

Application:	ELISA, FC, IF, IHC
Areas of Research:	Chromatin Remodeling
Clonality:	Monoclonal
Conjugate:	Unconjugated
Host:	HEK293F Cell
Isotype:	Rabbit IgG
Purification:	Affinity Chromatography
Reactivity:	Human
Recombinant:	Yes

A73721-050	50µl	$299.00
A73721-100	100µl	$399.00

Antibodies

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Displaying 1741 to 1760 (of 2673 products)

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