BackgroundPotent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.
DescriptionCD59 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationLiquid. 0.03% Proclin 300. 50% Glycerol, 0.01M PBS, pH 7.4.
SpecificityHuman
IsotypeIgG
Uniprot IDP13987
PurificationProtein G purified
ImmunogenRecombinant Human CD59 glycoprotein protein (26-102AA)
StorageShipped at 4°C. Upon delivery aliquot and store at -20°C (short-term) or -80°C (long-term). Avoid repeated freeze.
Alternative Names1F5 antigen 20 kDa homologous restriction factor MAC-inhibitory protein MEM43 antigen Membrane attack complex inhibition factor Membrane inhibitor of reactive lysis Protectin CD_antigen=CD59 CD59 MIC11, MIN1, MIN2, MIN3, MSK21
ApplicationELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200