BackgroundPromotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
DescriptionPhospho-MAPT (S324) Recombinant Monoclonal Antibody [4E8]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP10636
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Phospho-MAPT (S324)
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesMicrotubule-associated protein tau, Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau, MAPT, MAPTL, MTBT1, TAU
ApplicationELISA, IF; Recommended dilution: IF:1:20-1:200