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Histone Methylation Antibodies

Histone Methylation Antibodies

Histone methylation is associated with transcriptional repression or activation via the transfer of methyl groups to amino acids of histone proteins and is crucial to studying epigenetic gene regulation with the use of histone methylation antibodies. Histone methylation is implicated in the modification of chromatin structure and occurs on lysine and arginine residues. Histone methyltransferase and histone demethyltransferase activity is connected to transcriptional repression and activation. H3K4, H3K48, and H3K79 are sites known to activate genes whereas H3K9 and H3K27 are sites known to inactivate genes.
Histone Lysine Methylation Antibodies
Histone lysine methylation is a well-established transcriptional mechanism for regulating gene expression in eukaryotic cells. Histone N-terminal tails are susceptible to post-translational modifications (PTMs) and can influence many biological processes including transcription, replication, and chromosome maintenance. Methylation of lysine residues within histones is tightly regulated by methyltransferases (KMTs) and demethylases (KDMs) to preserve cell fate and genomic stability.

Histone Arginine Methylation Antibodies
Arginine methylation is a broadly expressed post-translational modification that occurs on both nuclear and cytoplasmic proteins. It is especially profuse on proteins that can shuttle continuously between the nucleus and the cytoplasm. The family of protein arginine methyltransferases (PRMTs) catalyzes methylation reactions, including target histones. Histone arginine methylation, which transpires on the tails of histone, can encourage or prevent the docking of key transcriptional effe...

Other Histone Methylation Antibodies
Histone methylation occurs with the addition of a methyl group to the amino-terminal tails of histone proteins. Depending on how many methyl groups are added and which amino acid residue is modified, histone methylation can have a positive or negative effect on gene transcription. Histone methyltransferases (HMTs) are enzymes that catalyze the addition of methyl groups to histone proteins, while histone demethylases (HDMs) remove these methyl groups. This process is important f...

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