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Development & Differentiation Antibodies

Development and differentiation includes processes by which a multicellular organism starts out from a single cell, a zygote, and gives rise to multiple cell types, forming different tissues and organs. Development comprises cell division, tissue and organ formation, body axis determination and cellular differentiation.

During development, cells must divide to form tissues and organs, while also they must differentiate into many diverse cell types with their distinctive features and functions. The totipotent zygote can give rise to all the cell types in the body and the placenta. As development progresses, cells potential to make up all cell types diminishes, and the embryonic stem cells become pluripotent, being able to give rise to all the cells of the body, except the placenta. The cells later differentiate into 3 germ layers: ectoderm, mesoderm and endoderm, and they conserve the ability to give rise to the cell types in their own lineage and not others. This is mostly under genetic control and different cell types start expressing different gene sets.

Differentiation is the process in which a cell develops its final cell type identity, and specific gene expression patterns allow the cell to synthesize RNA and protein specific for their structure and function. Not all cells in the body differentiate, some cells retain their ability to divide and produce multiple cell types. These include adult stem cells and cord blood stem cells, which are multipotent, as they have the ability to produce more than one cell type, but not all cell types. Hematopoietic stem cells are adult stem cells which give rise to the different cell types in blood. Stem cells undergo asymmetric cell division, producing two different daughter cells, one preserves the ability to self-renew and continues to be a stem cell, while the other becomes a differentiated cell.

An important group of genes controlling cellular differentiation during development are the HOX genes. They are not expressed in embryonic stem cells, but are expressed later by tissue stem cells in order to differentiate into their lineages and they are involved in determination of anterior-posterior body axis. Embryonic stem cells express transcription factors important for pluripotency, such as NANOG and OCT3/4 (POU5F1). Somatic cells can be reprogrammed to become induced pluripotent cells (iPS) by introducing transcription factors SOX2, KLF4, NANOG and OCT3/4.
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HOXD8 Polyclonal Antibody
HOXD8 Polyclonal Antibody

Application: ELISA, WB
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human, Mouse
Trial Size Available: Yes
A68583-02020 µg $99.00 Add to Cart
A68583-05050 µg $249.00 Add to Cart
A68583-100100 µg $399.00 Add to Cart
Antibodies
HOXD8 Polyclonal Antibody, Biotin Conjugated
HOXD8 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68586-05050 µg $249.00 Add to Cart
A68586-100100 µg $399.00 Add to Cart
Antibodies
HOXD8 Polyclonal Antibody, FITC Conjugated
HOXD8 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68585-05050 µg $249.00 Add to Cart
A68585-100100 µg $399.00 Add to Cart
Antibodies
HOXD8 Polyclonal Antibody, HRP Conjugated
HOXD8 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68584-05050 µg $249.00 Add to Cart
A68584-100100 µg $399.00 Add to Cart
Antibodies
IFRD2 Polyclonal Antibody
IFRD2 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A59466-02020 µg $99.00 Add to Cart
A59466-05050 µg $256.00 Add to Cart
A59466-100100 µg $359.00 Add to Cart
Antibodies
IFRD2 Polyclonal Antibody, Biotin Conjugated
IFRD2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A59467-05050 µg $256.00 Add to Cart
A59467-100100 µg $359.00 Add to Cart
Antibodies
IFRD2 Polyclonal Antibody, FITC Conjugated
IFRD2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A59468-05050 µg $256.00 Add to Cart
A59468-100100 µg $359.00 Add to Cart
Antibodies
IFRD2 Polyclonal Antibody, HRP Conjugated
IFRD2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A59469-05050 µg $256.00 Add to Cart
A59469-100100 µg $359.00 Add to Cart
Antibodies
IL1RAPL1 Polyclonal Antibody
IL1RAPL1 Polyclonal Antibody

Application: ELISA, IF, IHC, WB
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A69551-02020 µg $99.00 Add to Cart
A69551-05050 µg $249.00 Add to Cart
A69551-100100 µg $399.00 Add to Cart
Antibodies
IL1RAPL1 Polyclonal Antibody, Biotin Conjugated
IL1RAPL1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69554-05050 µg $249.00 Add to Cart
A69554-100100 µg $399.00 Add to Cart
Antibodies
IL1RAPL1 Polyclonal Antibody, FITC Conjugated
IL1RAPL1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69553-05050 µg $249.00 Add to Cart
A69553-100100 µg $399.00 Add to Cart
Antibodies
IL1RAPL1 Polyclonal Antibody, HRP Conjugated
IL1RAPL1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69552-05050 µg $249.00 Add to Cart
A69552-100100 µg $399.00 Add to Cart
Antibodies
KIAA0319 Polyclonal Antibody
KIAA0319 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A68779-02020 µg $99.00 Add to Cart
A68779-05050 µg $249.00 Add to Cart
A68779-100100 µg $399.00 Add to Cart
Antibodies
KIAA0319 Polyclonal Antibody, Biotin Conjugated
KIAA0319 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68782-05050 µg $249.00 Add to Cart
A68782-100100 µg $399.00 Add to Cart
Antibodies
KIAA0319 Polyclonal Antibody, FITC Conjugated
KIAA0319 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68781-05050 µg $249.00 Add to Cart
A68781-100100 µg $399.00 Add to Cart
Antibodies
KIAA0319 Polyclonal Antibody, HRP Conjugated
KIAA0319 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68780-05050 µg $249.00 Add to Cart
A68780-100100 µg $399.00 Add to Cart
Antibodies
KRT1 Polyclonal Antibody
KRT1 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A69567-02020 µg $99.00 Add to Cart
A69567-05050 µg $249.00 Add to Cart
A69567-100100 µg $399.00 Add to Cart
Antibodies
KRT1 Polyclonal Antibody, Biotin Conjugated
KRT1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69570-05050 µg $249.00 Add to Cart
A69570-100100 µg $399.00 Add to Cart
Antibodies
KRT1 Polyclonal Antibody, FITC Conjugated
KRT1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69569-05050 µg $249.00 Add to Cart
A69569-100100 µg $399.00 Add to Cart
Antibodies
KRT1 Polyclonal Antibody, HRP Conjugated
KRT1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69568-05050 µg $249.00 Add to Cart
A69568-100100 µg $399.00 Add to Cart
Antibodies
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