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Introduction to Epigenetics
Chromatin & Transcription Antibodies

Chromatin & Transcription Antibodies

Antibodies that target proteins associated with chromatin and transcription such as histone deacetylases (HDACs), histone acetyltransferases (HATs), histone methyltransferases (HMTs), and heterochromatin protein 1 (HP1) are important to understanding the epigenetic regulation of chromatin structure and its function. Chromatin is involved in crucial functions of the cell including division, replication, and gene expression.

structure of chromatin, histones, DNAChromatin remodeling antibodies may assist researchers in investigating several families of chromatin remodelers in eukaryotes, including the SWI/SNF, ISWI, CHD, and INO80 family of chromatin remodelers. These chromatin remodeling families share a conserved ATPase domain for ATP-hydrolysis and DNA binding. Other families have epigenetic reader domains which allow them to bind methylated histones or acetylated histones, for example. Many researchers study chromatin remodeling and protein-DNA interactions with ChIP.

DNA replication & transcription antibodies are useful especially for studying the regulation of gene expression. Transcription factors are proteins that bind to DNA that can alter the expression of certain genes. Transcription factors might also catalyze histone acetylation or histone deacetylation. Certain stimuli during development can lead transcription factors to downregulate or upregulate gene expression at particular times, ensuring proper growth. They are also highly implicated in cancer research as they can act as oncogenes or tumor suppressors.

Cell growth antibodies can be used by epigenetic researchers to investigate transcription factors which activate the expression of certain gene sets related to cell cycle progression and cellular growth. For example, the E2F family of transcription factors controls the progression of the cell cycle by inducing the transcription of genes needed to enter into the cell cycle’s S-phase.

Development & differentiation antibodies offer insight into the process by which an organism develops from a single cell and forms into multiple types of cells, creating various organs and tissues. For example, the HOX genes are an important group of genes that control cellular differentiation during development. They are expressed later in the process of development by tissue stem cells in order to differentiate into their lineages. In addition, embryonic stem cells express transcription factors crucial for pluripotency, such as NANOG and OCT3/4 (POU5F1). Somatic cells can be reprogrammed to become induced pluripotent cells (iPS) by introducing transcription factors SOX2, KLF4, NANOG and OCT3/4.
Chromatin Remodeling Antibodies
Chromatin remodeling refers to structural changes in chromatin that transform chromatin from a tight condensed conformation to a looser more permissive conformation. This allows access of transcription factors and other gene regulatory proteins to the DNA, leading to gene activation. Such changes are predominantly mediated by histone modifying enzymes, which catalyze the addition or removal of post-translational modifications to histones, and by several multiprotein chromatin remodeling complexes, which can alter nucleosome positioning. Besides its key role in regulating transcription and gene expression, chromatin remodeling is crucial for DNA replication and repair, as well as other cellular processes.

DNA Replication & Transcription Antibodies
DNA replication is the process by which DNA is duplicated or copied prior to cell division, and which allows the daughter cell to retain a set of its own genetic material. During this process, the two DNA strands are unwound by helicases forming replication forks, and DNA is copied by DNA polymerases to form daughter DNA strands. In eukaryotic cells, the nucleosomes at replication forks must be disassembled and then assembled back. DNA replication progresses by duplication of the DNA at several replication origins. DNA replication follows a semiconservative model, where each daughter cell retains an original parental DNA strand and a newly synthesized daughter strand.

Cell Growth Antibodies
Cell growth can refer to an increase in cell number, by proliferation and cell division, or to an increase in the cells volume, without cell division. Growth of a cell population or cell doubling is dependent on cell division, and involves the completion of successive cell cycles. Cell growth in terms of volume, is when the cytoplasm and organelles of a cell increase in volume due to increased transcription and protein synthesis. This occurs during G1 and G2 phases of the cell cycle, in preparation of the cell prior to DNA duplication during S-phase, or prior to cell division into two daughter cells during the mitotic phase.

Development & Differentiation Antibodies
Development and differentiation includes processes by which a multicellular organism starts out from a single cell, a zygote, and gives rise to multiple cell types, forming different tissues and organs. Development comprises cell division, tissue and organ formation, body axis determination and cellular differentiation.

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ANKRA2 Polyclonal Antibody, FITC Conjugated
ANKRA2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67512-05050 µg $256.00 Add to Cart
A67512-100100 µg $359.00 Add to Cart
Antibodies
ANKRA2 Polyclonal Antibody, HRP Conjugated
ANKRA2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A67511-05050 µg $256.00 Add to Cart
A67511-100100 µg $359.00 Add to Cart
Antibodies
ANKRD23 Polyclonal Antibody
ANKRD23 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Cellular Structure, Transcription Factors
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human, Mouse
Trial Size Available: Yes
A65982-02020 µg $59.00 Add to Cart
A65982-05050 µg $256.00 Add to Cart
A65982-100100 µg $359.00 Add to Cart
Antibodies
ANKRD23 Polyclonal Antibody, Biotin Conjugated
ANKRD23 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cellular Structure, Transcription Factors
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A65985-05050 µg $256.00 Add to Cart
A65985-100100 µg $359.00 Add to Cart
Antibodies
ANKRD23 Polyclonal Antibody, FITC Conjugated
ANKRD23 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cellular Structure, Transcription Factors
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A65984-05050 µg $256.00 Add to Cart
A65984-100100 µg $359.00 Add to Cart
Antibodies
ANKRD23 Polyclonal Antibody, HRP Conjugated
ANKRD23 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cellular Structure, Transcription Factors
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A65983-05050 µg $256.00 Add to Cart
A65983-100100 µg $359.00 Add to Cart
Antibodies
ANKRD33 Polyclonal Antibody
ANKRD33 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A65790-02020 µg $59.00 Add to Cart
A65790-05050 µg $256.00 Add to Cart
A65790-100100 µg $359.00 Add to Cart
Antibodies
ANKRD33 Polyclonal Antibody, Biotin Conjugated
ANKRD33 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A65793-05050 µg $256.00 Add to Cart
A65793-100100 µg $359.00 Add to Cart
Antibodies
ANKRD33 Polyclonal Antibody, FITC Conjugated
ANKRD33 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A65792-05050 µg $256.00 Add to Cart
A65792-100100 µg $359.00 Add to Cart
Antibodies
ANKRD33 Polyclonal Antibody, HRP Conjugated
ANKRD33 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Transcription Factors
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A65791-05050 µg $256.00 Add to Cart
A65791-100100 µg $359.00 Add to Cart
Antibodies
ANKRD49 Polyclonal Antibody
ANKRD49 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Apoptosis & Cell Death, Cell Development & Differentiation, Transcription Factors
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A66554-02020 µg $59.00 Add to Cart
A66554-05050 µg $256.00 Add to Cart
A66554-100100 µg $359.00 Add to Cart
Antibodies
ANKRD49 Polyclonal Antibody, Biotin Conjugated
ANKRD49 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Apoptosis & Cell Death, Cell Development & Differentiation, Transcription Factors
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A66557-05050 µg $256.00 Add to Cart
A66557-100100 µg $359.00 Add to Cart
Antibodies
ANKRD49 Polyclonal Antibody, FITC Conjugated
ANKRD49 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Apoptosis & Cell Death, Cell Development & Differentiation, Transcription Factors
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A66556-05050 µg $256.00 Add to Cart
A66556-100100 µg $359.00 Add to Cart
Antibodies
ANKRD49 Polyclonal Antibody, HRP Conjugated
ANKRD49 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Apoptosis & Cell Death, Cell Development & Differentiation, Transcription Factors
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A66555-05050 µg $256.00 Add to Cart
A66555-100100 µg $359.00 Add to Cart
Antibodies
ANKRD7 Polyclonal Antibody
ANKRD7 Polyclonal Antibody

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A58078-02020 µg $59.00 Add to Cart
A58078-05050 µg $256.00 Add to Cart
A58078-100100 µg $359.00 Add to Cart
Antibodies
ANKRD7 Polyclonal Antibody, Biotin Conjugated
ANKRD7 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58079-05050 µg $256.00 Add to Cart
A58079-100100 µg $359.00 Add to Cart
Antibodies
ANKRD7 Polyclonal Antibody, FITC Conjugated
ANKRD7 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58080-05050 µg $256.00 Add to Cart
A58080-100100 µg $359.00 Add to Cart
Antibodies
ANKRD7 Polyclonal Antibody, HRP Conjugated
ANKRD7 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58081-05050 µg $256.00 Add to Cart
A58081-100100 µg $359.00 Add to Cart
Antibodies
ARMC8 Polyclonal Antibody
ARMC8 Polyclonal Antibody

Application: ELISA
Areas of Research: Cell Growth, Cellular Structure
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A58154-02020 µg $59.00 Add to Cart
A58154-05050 µg $256.00 Add to Cart
A58154-100100 µg $359.00 Add to Cart
Antibodies
ARMC8 Polyclonal Antibody, Biotin Conjugated
ARMC8 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Growth, Cellular Structure
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: >95%, Protein G Purified
Reactivity: Human
A58155-05050 µg $256.00 Add to Cart
A58155-100100 µg $359.00 Add to Cart
Antibodies
Result Pages: [<< Prev]   1  2  3  4  5 ...  [Next >>]  Displaying 41 to 60 (of 2267 products)
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