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Application: Enzyme Inhibition
Molecular Weight: 100-500
Research Area: Histone Acetylation
Solubility: DMSO, Ethanol
100% Guarantee: 6 months
Catalog No.SizePriceQty
M47000-15 mg $449.00 
Availability: Usually Ships In 1-2 Days 
Product Overview

Alternative Names

Cambinol  is a cell-permeable β-naphthol compound that inhibits the NAD-dependent deacetylase activity of hSIRT1 and hSIRT2 (IC50 = 56 µM and 59 µM, respectively) in a substrate-, but not NAD-, competitive manner. It inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 µM) and exhibits no inhibition against class I and II HDACs. Cambinol-induced apoptosis in BCL6-expressing Burkitt lymphoma cell lines has been attributed to the hyperacetylation of BCL6 and p53. Shown to effectively inhibit xenografted Daudi Burkitt lymphoma growth in mice in vivo.

CAS Number

Chemical Formula

Molecular Weight

5 mg


Soluble in DMSO or EtOH

Storage Temp

User Guide & MSDS

[User Guide]*
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