Alternative Names5-[(2-hydroxy-5,8-dihydronaphthalen-1-yl)methyl]-6-phenyl-2-thioxo-2,3-dihy.DescriptionCambinol is a cell-permeable β-naphthol compound that inhibits the NAD-dependent deacetylase activity of hSIRT1 and hSIRT2 (IC50 = 56 µM and 59 µM, respectively) in a substrate-, but not NAD-, competitive manner. It inhibits SIRT5 deacetylase activity only at much higher concentrations (IC50 >300 µM) and exhibits no inhibition against class I and II HDACs. Cambinol-induced apoptosis in BCL6-expressing Burkitt lymphoma cell lines has been attributed to the hyperacetylation of BCL6 and p53. Shown to effectively inhibit xenografted Daudi Burkitt lymphoma growth in mice in vivo.CAS Number14513-15-6Chemical FormulaC21H16N2O2SMolecular Weight360.4
Size5 mg
Purity>95%SolubilitySoluble in DMSO or EtOHStorage Temp-20°C