Ubiquitination & SUMOylation Antibodies

Ubiquitination and sumoylation are post-translational modifications (PTMs) of proteins that regulate various cellular processes.

Ubiquitination: A small protein called ubiquitin is added to a target protein, resulting in the targeting of the protein for degradation by the proteasome, or in the alteration of its function or localization.

Sumoylation: A small protein called SUMO (small ubiquitin-like modifier) is added to a target protein, it can also alter the protein's function, localization, or stability, although this PTM typically stabilizes proteins and protects them from degradation.

Both ubiquitination and sumoylation are mediated by specific enzymes called E3 ubiquitin ligases and SUMO ligases, respectively. These enzymes recognize specific sequences in the target protein and transfer the ubiquitin or SUMO protein to a lysine residue on the target protein.

Ubiquitination has been known to affect proteins by altering cellular location, impacting protein activity, and adjusting protein-protein interactions. Research shows that sumoylation regulates protein-protein interactions and subcellular targeting and is involved in numerous processes such as nuclear-cytosolic transport, apoptosis, transcriptional regulation, response to stress, protein stability, and progression through the cell cycle.

Ubiquitination antibodies and sumoylation antibodies are thus useful tools to researchers investigating the control mechanisms associated with numerous nuclear proteins.

What makes buying antibodies from EpiGentek different?

At EpiGentek, we supply a collection of over 20,000 individual high-quality antibodies for our customers to ensure that our research customers find exactly what they need for their studies. In addition, we offer a variety of other benefits to help our customers in terms of affordability, convenience, and reliability. See why working with EpiGentek for your antibodies is the right choice:

• No Shipping & Handling Costs: we’ve waived all shipping and handling fees on our antibodies and antibody panel packs when selecting 2-day shipping (trial sizes not applicable).
• 100% Application Guarantee: your purchased antibodies are covered for 6-months past the date of purchase.
• Multiple Conjugates: we carry biotin, FITC and HRP conjugates for nearly all targets.
• Trial Sizes Available: 10 & 20 µl options available for thousands of antibodies in our catalog.