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Development & Differentiation Antibodies

Development and differentiation includes processes by which a multicellular organism starts out from a single cell, a zygote, and gives rise to multiple cell types, forming different tissues and organs. Development comprises cell division, tissue and organ formation, body axis determination and cellular differentiation.

During development, cells must divide to form tissues and organs, while also they must differentiate into many diverse cell types with their distinctive features and functions. The totipotent zygote can give rise to all the cell types in the body and the placenta. As development progresses, cells potential to make up all cell types diminishes, and the embryonic stem cells become pluripotent, being able to give rise to all the cells of the body, except the placenta. The cells later differentiate into 3 germ layers: ectoderm, mesoderm and endoderm, and they conserve the ability to give rise to the cell types in their own lineage and not others. This is mostly under genetic control and different cell types start expressing different gene sets.

Differentiation is the process in which a cell develops its final cell type identity, and specific gene expression patterns allow the cell to synthesize RNA and protein specific for their structure and function. Not all cells in the body differentiate, some cells retain their ability to divide and produce multiple cell types. These include adult stem cells and cord blood stem cells, which are multipotent, as they have the ability to produce more than one cell type, but not all cell types. Hematopoietic stem cells are adult stem cells which give rise to the different cell types in blood. Stem cells undergo asymmetric cell division, producing two different daughter cells, one preserves the ability to self-renew and continues to be a stem cell, while the other becomes a differentiated cell.

An important group of genes controlling cellular differentiation during development are the HOX genes. They are not expressed in embryonic stem cells, but are expressed later by tissue stem cells in order to differentiate into their lineages and they are involved in determination of anterior-posterior body axis. Embryonic stem cells express transcription factors important for pluripotency, such as NANOG and OCT3/4 (POU5F1). Somatic cells can be reprogrammed to become induced pluripotent cells (iPS) by introducing transcription factors SOX2, KLF4, NANOG and OCT3/4.
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RNF39 Polyclonal Antibody
RNF39 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A68699-02020 µg $99.00 Add to Cart
A68699-05050 µg $249.00 Add to Cart
A68699-100100 µg $399.00 Add to Cart
Antibodies
RNF39 Polyclonal Antibody, Biotin Conjugated
RNF39 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68702-05050 µg $249.00 Add to Cart
A68702-100100 µg $399.00 Add to Cart
Antibodies
RNF39 Polyclonal Antibody, FITC Conjugated
RNF39 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68701-05050 µg $249.00 Add to Cart
A68701-100100 µg $399.00 Add to Cart
Antibodies
RNF39 Polyclonal Antibody, HRP Conjugated
RNF39 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A68700-05050 µg $249.00 Add to Cart
A68700-100100 µg $399.00 Add to Cart
Antibodies
ROGDI Polyclonal Antibody
ROGDI Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
Trial Size Available: Yes
A60666-02020 µg $99.00 Add to Cart
A60666-05050 µg $256.00 Add to Cart
A60666-100100 µg $359.00 Add to Cart
Antibodies
ROGDI Polyclonal Antibody, Biotin Conjugated
ROGDI Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
A60667-05050 µg $256.00 Add to Cart
A60667-100100 µg $359.00 Add to Cart
Antibodies
ROGDI Polyclonal Antibody, FITC Conjugated
ROGDI Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
A60668-05050 µg $256.00 Add to Cart
A60668-100100 µg $359.00 Add to Cart
Antibodies
ROGDI Polyclonal Antibody, HRP Conjugated
ROGDI Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human
A60669-05050 µg $256.00 Add to Cart
A60669-100100 µg $359.00 Add to Cart
Antibodies
RTN4IP1 Polyclonal Antibody
RTN4IP1 Polyclonal Antibody

Application: ELISA, IHC
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A60738-02020 µg $99.00 Add to Cart
A60738-05050 µg $256.00 Add to Cart
A60738-100100 µg $359.00 Add to Cart
Antibodies
RTN4IP1 Polyclonal Antibody, Biotin Conjugated
RTN4IP1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A60739-05050 µg $256.00 Add to Cart
A60739-100100 µg $359.00 Add to Cart
Antibodies
RTN4IP1 Polyclonal Antibody, FITC Conjugated
RTN4IP1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A60740-05050 µg $256.00 Add to Cart
A60740-100100 µg $359.00 Add to Cart
Antibodies
RTN4IP1 Polyclonal Antibody, HRP Conjugated
RTN4IP1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A60741-05050 µg $256.00 Add to Cart
A60741-100100 µg $359.00 Add to Cart
Antibodies
RTN4RL1 Polyclonal Antibody
RTN4RL1 Polyclonal Antibody

Application: ELISA, IF, IHC
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
Trial Size Available: Yes
A65990-02020 µg $99.00 Add to Cart
A65990-05050 µg $256.00 Add to Cart
A65990-100100 µg $359.00 Add to Cart
Antibodies
RTN4RL1 Polyclonal Antibody, Biotin Conjugated
RTN4RL1 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A65993-05050 µg $256.00 Add to Cart
A65993-100100 µg $359.00 Add to Cart
Antibodies
RTN4RL1 Polyclonal Antibody, FITC Conjugated
RTN4RL1 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A65992-05050 µg $256.00 Add to Cart
A65992-100100 µg $359.00 Add to Cart
Antibodies
RTN4RL1 Polyclonal Antibody, HRP Conjugated
RTN4RL1 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A65991-05050 µg $256.00 Add to Cart
A65991-100100 µg $359.00 Add to Cart
Antibodies
SCUBE2 Polyclonal Antibody
SCUBE2 Polyclonal Antibody

Application: ELISA, IHC, WB
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human, Rat
Trial Size Available: Yes
A69183-02020 µg $99.00 Add to Cart
A69183-05050 µg $249.00 Add to Cart
A69183-100100 µg $399.00 Add to Cart
Antibodies
SCUBE2 Polyclonal Antibody, Biotin Conjugated
SCUBE2 Polyclonal Antibody, Biotin Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: Biotin
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69186-05050 µg $249.00 Add to Cart
A69186-100100 µg $399.00 Add to Cart
Antibodies
SCUBE2 Polyclonal Antibody, FITC Conjugated
SCUBE2 Polyclonal Antibody, FITC Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: FITC
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69185-05050 µg $249.00 Add to Cart
A69185-100100 µg $399.00 Add to Cart
Antibodies
SCUBE2 Polyclonal Antibody, HRP Conjugated
SCUBE2 Polyclonal Antibody, HRP Conjugated

Application: ELISA
Areas of Research: Cell Development & Differentiation
Clonality: Polyclonal
Conjugate: HRP
Host: Rabbit
Isotype: IgG
Purification: Protein G Purified
Reactivity: Human
A69184-05050 µg $249.00 Add to Cart
A69184-100100 µg $399.00 Add to Cart
Antibodies
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