AA, 2-Hydroxy-6-pentadecylbenzoic Acid, 6-Pentadecylsalicylic Acid
Anacardic Acid is a pentadecane aliphatic chain containing hydroxylcarboxylic acid. The acid is an effective inhibitor of the activities of p300 and p300/CBP associated factor histone acetyltransferase. Additionally, it has been shown to potently inhibit HAT-dependent transcription and SUMOylation, as well as decrease expression of NF-κB regulated gene products including, invasion, proliferation, inflammation, and cell survival. Research suggests that anacardic acid may be a potent activator of ARK-1 (Aurora kinase A) mediated phosphorylation of histone H3, and a novel activator of Aurora kinase. Anacardic Acid has demonstrated bactericidal activity against methicillin-resistant Staphylococcus aureus (MRSA).
Soluble in 100% ethanol, methanol, DMSO, dichloromethane or ethylacetate