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   Home  »  CUT&RUN-Based MeRIP and MeRIP-seq Kits for m6A RNA-Protein Interaction 
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CUT&RUN m6A MeRIP and m6A-Seq kits
EpiQuik™ CUT&RUN m6A RNA Enrichment (MeRIP) Kit box and components

EpiQuik™ CUT&RUN m6A RNA Enrichment (MeRIP) Kit & EpiNext™ CUT&RUN RNA m6A-Seq Kit

Reliable, streamlined solutions for m6A enrichment and sequencing—faster workflows, higher specificity, and consistent results with minimal input.

Comprehensive m6A RNA Analysis: Enrichment and Sequencing Kits

Standard curve and sample analysis for m6A RNA methylation using CUT&RUN enrichment
m6A RNA fragments were enriched with the EpiQuik™ CUT&RUN m6A RNA Enrichment Kit, purified, and fluorescently quantified for fold comparison.
Size distribution of m6A-enriched RNA fragments showing ~195 bp peak (~55 bp inserts)
Size distribution of m6A-enriched RNA libraries using the EpiNext™ CUT&RUN RNA m6A-Seq Kit; 195 bp peak reflects ~55 bp insert.


The CUT&RUN m6A RNA kits provide a next-generation approach for precise RNA methylation profiling, delivering fast, reliable, and high-resolution enrichment with minimal input.

  • High enrichment: Unique cleavage enzyme mix generates short antibody-bound fragments close to m6A sites for precise mapping.
  • Low input: Single-tube cleavage & capture protects targets and minimizes loss; works from as little as 500 ng RNA.
  • Minimal background: Cleavage of unbound RNA at both ends reduces MeRIP-seq background—reliable analysis with <10 M reads.
  • Fast & streamlined: From RNA to enriched m6A RNA in 2.5 hours (<30 min hands-on) or to library cDNA in <6 hours (<1 h hands-on).
  • Highly convenient: Includes all components for cleavage, capture and (when applicable) library prep for consistent, reproducible results.
  • Proven & trusted: Highly cited in over 100 peer-reviewed studies.

Consistent, convenient, and streamlined—accurate m6A profiling in hours for qRT-PCR or NGS.

Compare CUT&RUN m6A RNA Enrichment (MeRIP) Kits

Feature EpiQuik™ CUT&RUN m6A RNA Enrichment (MeRIP) Kit Competitor M
Workflow Convenience ✅ Streamlined (total 17 steps) ❌ Labor-intensive (>40 steps; must optimize shearing)
Protocol Time ✅ Fast (~2.5 hrs) ❌ Slow (~6.5 hrs)
Minimum RNA Input ✅ Low (0.5 µg) ❌ Very high (300 µg)
Sequence Resolution ✅ High (cleavage very close to antibody/m6A binding site) ❌ Low (shearing variability affects fragmentation efficiency)
Cost per Reaction ✅ Affordable ($18 – $20) ❌ Very expensive (>$100)

Featured in the world’s leading scientific journals

Our CUT&RUN m6A RNA Enrichment (MeRIP) Kit & CUT&RUN RNA m6A-Seq Kit are trusted by leading researchers and highly cited in top-tier publications with high impact factors, fueling groundbreaking discoveries.

Nature Communications

Impact Factor: 17.7

Shiraishi C et al. (Apr 2023). RPL3L-containing ribosomes determine translation elongation dynamics required for cardiac function. Nat Commun.

EpiNext™ CUT&RUN RNA m6A-Seq Kit
Nucleic Acids Research

Impact Factor: 16.9

Liang Z et al. (Aug 2024). ALKBH5 governs human endoderm fate via DKK1/4-mediated Wnt/β-catenin activation. Nucleic Acids Res.

EpiQuik™ CUT&RUN MeRIP Kit
Journal for ImmunoTherapy of Cancer

Impact Factor: 14.0

Tong Y et al. (Apr 2025). METTL3 promotes an immunosuppressive microenvironment in bladder cancer. J Immunother Cancer.

EpiQuik™ CUT&RUN MeRIP Kit
Free Radical Biology and Medicine

Impact Factor: 13.45

Gao X et al. (Apr 2025). MSC-derived exosomes alleviate oxidative stress-induced lysosomal membrane permeabilization damage in degenerated nucleus pulposus cells via promoting m6A demethylation of Nrf2. Free Radic Biol Med.

EpiQuik™ CUT&RUN MeRIP Kit

Get fast, high-specificity m6A enrichment

Explore the Kits

Frequently asked questions

How much RNA input do I need?

As little as 500 ng of total RNA is sufficient for enrichment.

How long does the workflow take?

~2.5 hours for enrichment (<30 min hands-on); library cDNA in <6 hours (<1 h hands-on).

What read depth is recommended?

Reliable analysis can be achieved with fewer than 10 million reads owing to low background.

Which downstream applications are supported?

Enriched RNA is suitable for qRT-PCR and RNA-seq; the m6A-Seq kit produces sequencing-ready libraries.

Also Available: RNA Methylation Antibodies

Explore validated antibodies designed for reliable detection of RNA methylation, supporting a wide range of research applications.

Explore RNA Methylation Antibodies
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