BackgroundSIRT3 is a member of the sirtuin (silent mating type information regulation 2 homolog) family of proteins which are characterized by a sirtuin core domain and are grouped into 4 class types. Sirtuins share NAD dependency for their enzymatic activity, but some show NAD-dependent deacetylase activity, while others exhibit ADP ribosyltransferase activity or both. Sirtuins may act to influence a wide range of cellular processes such as aging, transcription, apoptosis, inflammation and stress resistance. Seven members make up the family of sirtuins in mammals (SirT1-T7). SIRT3 is a Class I sirtuin.
DescriptionSIRT3 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.01% thiomersal, 50% glycerol, pH7.3.
SpecificityHuman, Mouse, Rat
IsotypeIgG
Uniprot IDQ9NTG7
PurificationAffinity Purified
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 300-399 of human SIRT3 (NP_036371.1).
StorageShipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.
Alternative NamesSIR2L3
ApplicationWB, IHC, IF, IP; Recommended dilution: WB 1:500 - 1:1000, IHC 1:50 - 1:200, IP 1:50 - 1:500, IF 1:50 - 1:200