BackgroundKey player in eukaryotic cell cycle control, regulating centrosome cycle and mitotic onset. Promotes G2-M transition, modulates G1 progress and G1-S transition via interphase cyclins. Essential for S-phase entry, mitosis, embryonic development, and DNA repair. Phosphorylates numerous targets involved in processes such as centrosome separation, nuclear envelope breakdown, chromosome condensation, and apoptosis. Controls microtubule dynamics and spindle formation. Impacts cell cycle progression, genome replication, and DNA repair.
DescriptionPhospho-CDK1/CDK2/CDK3 (T14) Recombinant Monoclonal Antibody [4C12]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman
IsotypeRabbit IgG
Uniprot IDP06493/P24941/Q00526
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human Phospho-CDK1 (T14)
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesCyclin-dependent kinase 1, CDK1, Cell division control protein 2 homolog, Cell division protein kinase 1, p34 protein kinase, CDK1, CDC2, CDC28A, CDKN1, P34CDC2
ApplicationELISA, WB; Recommended dilution: WB:1:500-1:5000