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MTA2 Polyclonal Antibody

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Western blot analysis of extracts of various cell lines, using MTA2 Polyclonal Antibody.
Application: WB
Areas of Research: Chromatin Remodeling, Histone Acetylation & Deacetylation
Clonality: Polyclonal
Conjugate: Unconjugated
Host: Rabbit
Isotype: IgG
Purification: Affinity Purified
Reactivity: Human, Mouse, Rat
100% Guarantee: 6 months
Catalog No.SizePriceQty
A-2742-05050 µl $273.00 
A-2742-100100 µl $465.00 
Availability: Usually Ships in 3-4 Days 
Product Overview

Background
MTA2 (metastasis-associated protein) is a component of NuRD, a nucleosome remodeling deacetylase complex found in the nucleus of human cells. It demonstrates a very wide expression pattern and is highly expressed in various tissues. MTA2 represents only a single member of a small gene family that encode distinctive but related proteins involved in transcriptional regulation (either directly or indirectly). Chromatin remodeling may be an indirect effect of their transcriptional regulation. MTA2 is very similar to and shares domain types with another member of this family, a protein associated with metastatic carcinomas potential. The shared domains include two DNA binding domains, a dimerization domain, and a domain generally found in proteins that methylate DNA. A target protein for this gene is p53, and deacetylation of p53 is associated with reduced growth inhibition in transformed cells, thus indicating a role for these gene family members in metastasis.

Description
MTA2 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.

Specificity
Human, Mouse, Rat

Isotype
IgG

Uniprot ID
O94776

Purification
Affinity Purified

Immunogen
Recombinant Protein of Human MTA2

Storage
Shipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.

Alternative Names
PID, MTA1L1

Application
WB

User Guide & MSDS

[User Guide]*
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