The protein encoded by this gene is similar to ING1, a tumor suppressor protein that can interact with TP53, inhibit cell growth, and induce apoptosis. This protein contains a PHD-finger, which is a common motif in proteins involved in chromatin remodeling. This gene can activate p53 trans-activated promoters, including promoters of p21/waf1 and bax. Overexpression of this gene has been shown to inhibit cell growth and induce apoptosis. Allelic loss and reduced expression of this gene were detected in head and neck cancers. Two alternatively spliced transcript variants encoding different isoforms have been observed.
ING3 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
Liquid. PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Human, Mouse, Rat
Recombinant Protein of Human ING3
Shipped at 4°C. Store at -20°C. Avoid multiple freeze/thaw cycles.
Eaf4, ING2, MEAF4, p47ING3
WB, IF; Recommended dilution: WB 1:500 - 1:2000 IF 1:50 - 1:200