BackgroundThis gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress the recombination of rDNA. Studies suggest that human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants.
DescriptionSIRT1 Polyclonal Antibody. Unconjugated. Raised in: Rabbit.
FormulationBuffer: PBS with 0.05% proclin300, 50% glycerol, pH7.3
SpecificityHuman, Mouse
IsotypeIgG
Uniprot IDQ96EB6
PurificationAffinity Purified
ImmunogenA synthetic peptide corresponding to a sequence within amino acids 200-300 of human SIRT1 (NP_036370.2)
StorageShipped at 4°C. Store at -20°C. Avoid freeze / thaw cycles.
Alternative NamesSIR2; SIR2L1; SIR2alpha; SIRT1; sirtuin 1
ApplicationWB, IHC; Recommended dilution: WB 1:500 - 1:2000, IHC 1:50 - 1:200