BackgroundThis protein is involved in various cellular functions: endocytosis, multivesicular body formation, membrane repair, cytokinesis, apoptosis, and maintaining tight junction integrity. It belongs to Class E VPS and helps concentrate and sort cargo proteins within multivesicular bodies. It binds to LBPA, abundant in MVB's internal membranes. The protein is crucial for cytokinesis completion, ESCRT-mediated membrane fission, and regulating apoptosis and cell proliferation. It collaborates with other proteins to control exosome formation and ensures proper assembly of the actomyosin-tight junction complex, maintaining cell polarity and barriers between adjacent cells.
DescriptionPDCD6IP Recombinant Monoclonal Antibody [7E9]. Unconjugated. Raised in: HEK293F Cell.
FormulationBuffer: Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
SpecificityHuman, Rat
IsotypeRabbit IgG
Uniprot IDQ8WUM4
PurificationAffinity Chromatography
ImmunogenA synthesized peptide derived from human ALIX
StorageUpon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Alternative NamesProgrammed cell death 6-interacting protein (PDCD6-interacting protein) (ALG-2-interacting protein 1) (ALG-2-interacting protein X) (Hp95), PDCD6IP, AIP1 ALIX KIAA1375
ApplicationELISA, WB, FC; Recommended dilution: WB:1:500-1:5000, FC:1:20-1:200